Honey-Loaded Egg White/Poly(vinyl alcohol)/Clay Bionanocomposite Hydrogel Wound Dressings: In Vitro and In Vivo Evaluations

被引:30
作者
Rafati, Zahra [1 ]
Sirousazar, Mohammad [1 ]
Hassan, Zuhair Muhammad [2 ]
Kheiri, Farshad [1 ]
机构
[1] Urmia Univ Technol, Fac Chem Engn, Orumiyeh, Iran
[2] Tarbiat Modares Univ, Fac Med Sci, Dept Immunol, Tehran, Iran
关键词
Bionanocomposite hydrogel; Wound dressing; Infection; Egg white; Poly(vinyl alcohol); Clay; Honey; NANOCOMPOSITE HYDROGELS; ANTIBACTERIAL; RELEASE;
D O I
10.1007/s10924-019-01586-w
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Bionanocomposite hydrogels are suitable candidates for the preparation of the ideal wound dressings due to their unique hydrophilic properties, biocompatibility and appropriate control in delivering therapeutic agents such as drugs, proteins and cells. In this work, bionanocomposite hydrogel wound dressings based on egg white, poly (vinyl alcohol) and clay nanoparticles loaded with honey, as a natural antibiotic, were prepared using the freezing-thawing cyclic process and their performances evaluated in vitro and in vivo as novel wound dressings. The results showed that the swelling and dehydration capabilities of the prepared bionanocomposite hydrogel wound dressings decreased by increasing the content of incorporated clay nanoparticles. Honey release test showed that the presence of clay nanoparticles acts as a key factor in the release of honey and causes control over its release from the wound dressings. The in vivo results exhibited the excellent ability of the honey-loaded bionanocomposite hydrogel wound dressings in the creation and keeping a moist region on the surface of the infected and non-infected wounds and their capability in accelerating the healing process of animal wounds.
引用
收藏
页码:32 / 46
页数:15
相关论文
共 35 条
  • [1] Hydrogel film loaded with new formula from manuka honey for treatment of chronic wound infections
    Abd El-Malek, Fady F.
    Yousef, Amany S.
    El-Assar, Samy A.
    [J]. JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2017, 11 : 171 - 176
  • [2] Radiation synthesis of nanosilver/poly vinyl alcohol/cellulose acetate/gelatin hydrogels for wound dressing
    Abd El-Mohdy, H. L.
    [J]. JOURNAL OF POLYMER RESEARCH, 2013, 20 (06)
  • [3] PVA/CM-chitosan/honey hydrogels prepared by using the combined technique of irradiation followed by freeze-thawing
    Afshari, M. J.
    Sheikh, N.
    Afarideh, H.
    [J]. RADIATION PHYSICS AND CHEMISTRY, 2015, 113 : 28 - 35
  • [4] Novel electrospun chitosan/polyvinyl alcohol/zinc oxide nanofibrous mats with antibacterial and antioxidant properties for diabetic wound healing
    Ahmed, Rashid
    Tariq, Muhammad
    Ali, Imran
    Asghar, Rehana
    Khanam, P. Noorunnisa
    Augustine, Robin
    Hasan, Anwarul
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 120 : 385 - 393
  • [5] [Anonymous], 2015, Guyton and Hall Textbook of Medical Physiology E-Book
  • [6] Electrospun polyvinyl alcohol membranes incorporated with green synthesized silver nanoparticles for wound dressing applications
    Augustine, Robin
    Hasan, Anwarul
    Nath, V. K. Yadu
    Thomas, Jince
    Augustine, Anitha
    Kalarikkal, Nandakumar
    Al Moustafa, Ala-Eddin
    Thomas, Sabu
    [J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2018, 29 (11)
  • [7] Biomedical applications of hydrogels: A review of patents and commercial products
    Calo, Enrica
    Khutoryanskiy, Vitaliy V.
    [J]. EUROPEAN POLYMER JOURNAL, 2015, 65 : 252 - 267
  • [8] Extremely strong and tough hydrogels as prospective candidates for tissue repair - A review
    Costa, Ana M. S.
    Mano, Joao F.
    [J]. EUROPEAN POLYMER JOURNAL, 2015, 72 : 344 - 364
  • [9] CORRELATION OF HIGH-SPEED TENSILE-STRENGTH WITH COLLAGEN CONTENT IN CONTROL AND LATHYRITIC RAT SKIN
    DOMBI, GW
    HAUT, RC
    SULLIVAN, WG
    [J]. JOURNAL OF SURGICAL RESEARCH, 1993, 54 (01) : 21 - 28
  • [10] Simple method of open skin wound healing model in corticosteroid-treated and diabetic rats: standardization of semi-quantitative and quantitative histological assessments
    Gal, P.
    Kilik, R.
    Mokry, M.
    Vidinsky, B.
    Vasilenko, T.
    Mozes, S.
    Bobrov, N.
    Tomori, Z.
    Bober, J.
    Lenhardt, L.
    [J]. VETERINARNI MEDICINA, 2008, 53 (12) : 652 - 659