A facile route for the synthesis of novel S-linked 1,3,5-triazine tethered peptidomimetics

被引：9
作者：
Krishnamurthy, Muniyappa [1 ]
Basavaprabhu [1 ]
Sharanabai, K. M. [1 ]
Sureshbabu, Vommina V. [1 ]
机构：
[1] Bangalore Univ, Dept Studies Chem, Peptide Res Lab, Bangalore 560001, Karnataka, India
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 41期
关键词：
N-alpha-protected amino alkyl isothiouronium salts; Amino acid ester; Formaldehyde; Dehydrocyclization; CONVENIENT SYNTHESIS; CHEMISTRY; DESIGN; ACIDS; ANALOGS; SERIES; PHASE;
D O I：
10.1016/j.tetlet.2014.08.075
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient one-pot synthesis of N-alpha-protected S-linked 1,3,5-triazine tethered peptidomimetics is described. The protocol involves a three-component condensation reaction employing N-alpha-protected amino alkyl isothiouronium salt, formaldehyde and amino acid ester or aryl amine as reactants. Various aryl amines with substitutions and amino acids with simple as well as bifunctional side chains were employed to obtain triazine tethered peptidomimetics in good yield. (C) 2014 Published by Elsevier Ltd.
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收藏
页码：5609 / 5612
页数：4
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