Galectin-3 and cancer

被引：0
作者：
Califice, S
Castronovo, V
Van Den Brûle, F
机构：
[1] Univ Liege, Mat Res Lab, B-4000 Liege, Belgium
[2] CHU Sart Tilman, Dept Obstet & Gynecol, B-4000 Liege, Belgium
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 2004年 / 25卷 / 04期
关键词：
cancer; galectin-3; extracellular matrix;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Galectin-3 is a pleiotropic carbohydrate-binding protein involved in a variety of normal and pathological biological processes. Its carbohydrate-binding properties constitute the basis for cell-cell and cell-matrix interactions and cancer progression. Modulation of galectin-3 expression in cancer cells has indeed been reported. These observations lead to the recognition of galectin-3 as a diagnostic/prognostic marker for specific cancer types, such as thyroid and prostate. This review discusses the expression and cellular localization of galectin-3 in cancer cells, as well as its numerous functions in cancer cell biology, including cell-cell adhesion, cell-matrix interactions, growth regulation, apoptosis, angiogenesis and mRNA splicing.
引用
收藏
页码：983 / 992
页数：10
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