Galectin-3 and cancer

被引：0
作者：
Califice, S
Castronovo, V
Van Den Brûle, F
机构：
[1] Univ Liege, Mat Res Lab, B-4000 Liege, Belgium
[2] CHU Sart Tilman, Dept Obstet & Gynecol, B-4000 Liege, Belgium
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 2004年 / 25卷 / 04期
关键词：
cancer; galectin-3; extracellular matrix;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Galectin-3 is a pleiotropic carbohydrate-binding protein involved in a variety of normal and pathological biological processes. Its carbohydrate-binding properties constitute the basis for cell-cell and cell-matrix interactions and cancer progression. Modulation of galectin-3 expression in cancer cells has indeed been reported. These observations lead to the recognition of galectin-3 as a diagnostic/prognostic marker for specific cancer types, such as thyroid and prostate. This review discusses the expression and cellular localization of galectin-3 in cancer cells, as well as its numerous functions in cancer cell biology, including cell-cell adhesion, cell-matrix interactions, growth regulation, apoptosis, angiogenesis and mRNA splicing.
引用
收藏
页码：983 / 992
页数：10
相关论文
共 185 条
[1]  
AGRWAL N, 1989, J BIOL CHEM, V264, P17236
[2]  
Akahani S, 1997, CANCER RES, V57, P5272
[3]   GALACTOSIDE-BINDING LECTIN IN HUMAN-TISSUES [J].
ALLEN, HJ ;
KARAKOUSIS, C ;
PIVER, MS ;
GAMARRA, M ;
NAVA, H ;
FORSYTH, B ;
MATECKI, B ;
JAZAYERI, A ;
SUCATO, D ;
KISAILUS, E ;
DICIOCCIO, R .
TUMOR BIOLOGY, 1987, 8 (04) :218-229
[4]   Galectins-1 and-3 and their ligands in tumor biology -: Non-uniform properties in cell-surface presentation and modulation of adhesion to matrix glycoproteins for various tumor cell lines, in biodistribution of free and liposome-bound galectins and in their expression by breast and colorectal carcinomas with/without metastatic propensity [J].
André, S ;
Kojima, S ;
Yamazaki, N ;
Fink, C ;
Kaltner, H ;
Kayser, K ;
Gabius, HJ .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1999, 125 (8-9) :461-474
[5]   Diagnostic utility of galectin-3 and CD26/DPPIV as preoperative diagnostic markers for thyroid nodules [J].
Aratake, Y ;
Umeki, K ;
Kiyoyama, K ;
Hinoura, Y ;
Sato, S ;
Ohno, A ;
Kuribayashi, T ;
Hirai, K ;
Nabeshima, K ;
Kotani, T .
DIAGNOSTIC CYTOPATHOLOGY, 2002, 26 (06) :366-372
[6]   Increased galectin-3 expression in gastric cancer:: Correlations with histopathological subtypes, galactosylated antigens and tumor cell proliferation [J].
Baldus, SE ;
Zirbes, TK ;
Weingarten, M ;
Fromm, S ;
Glossmann, J ;
Hanisch, FG ;
Mönig, SP ;
Schröder, W ;
Flucke, U ;
Thiele, J ;
Hölscher, AH ;
Dienes, HP .
TUMOR BIOLOGY, 2000, 21 (05) :258-266
[7]   GALECTINS - A FAMILY OF ANIMAL BETA-GALACTOSIDE-BINDING LECTINS [J].
BARONDES, SH ;
CASTRONOVO, V ;
COOPER, DNW ;
CUMMINGS, RD ;
DRICKAMER, K ;
FEIZI, T ;
GITT, MA ;
HIRABAYASHI, J ;
HUGHES, C ;
KASAI, K ;
LEFFLER, H ;
LIU, FT ;
LOTAN, R ;
MERCURIO, AM ;
MONSIGNY, M ;
PILLAI, S ;
POIRER, F ;
RAZ, A ;
RIGBY, PWJ ;
RINI, JM ;
WANG, JL .
CELL, 1994, 76 (04) :597-598
[8]  
BARONDES SH, 1994, J BIOL CHEM, V269, P20807
[9]   Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions [J].
Bartolazzi, A ;
Gasbarri, A ;
Papotti, M ;
Bussolati, G ;
Lucante, T ;
Khan, A ;
Inohara, H ;
Marandino, F ;
Orlandi, F ;
Nardi, F ;
Vecchione, A ;
Tecce, R ;
Larsson, O .
LANCET, 2001, 357 (9269) :1644-1650
[10]   Cytokeratin 19 and galectin-3 immunohistochemistry in the differential diagnosis of solitary thyroid nodules [J].
Beesley, MF ;
McLaren, KM .
HISTOPATHOLOGY, 2002, 41 (03) :236-243
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