Magnetohydrodynamic thermochemotherapy and MRI of mouse tumors

被引：25

作者：

Brusentsov, Nikolay A. ^{[1
]}

Brusentsova, Tatiana N.

Filinova, Elena Yu.

Jurchenko, Nikolay Y.

Kupriyanov, Dmitry A.

Pirogov, Yuri A.

Dubina, Andry I.

Shumskikh, Maxim N.

Shumakov, Leonid I.

Anashkina, Ekaterina N.

Shevelev, Alexandr A.

Uchevatkin, Andry A.

机构：

[1] Moscow MV Lomonosov State Univ, Inst Mech, Moscow 117192, Russia

[2] Russian Acad Med Sci, SE Russian NN Blokhin Canc Res Ctr, Moscow 115478, Russia

[3] Mendeleyev Univ Chem Technol Russia, Moscow 125047, Russia

[4] Moscow MV Lomonosov State Univ, Ctr Magnet Tomog & Spect, Moscow 119992, Russia

[5] All Russian Radio Tech Res Inst, Moscow 105082, Russia

[6] Russian State Med Univ, Moscow 117997, Russia

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2007年 / 311卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

nanoparticle; magnetohydrodynamic thermochemotherapy; P388; carcinoma; metastasis; MRI contrast agent; dextran; magnetic fluid; tumor;

D O I：

10.1016/j.jmmm.2006.11.159

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A dextran-ferrite magnetic fluid was successfully tested as magnetic resonance imaging (MRI) contrast agent. The same magnetic fluid was then combined with Melphalan, a chemotherapeutic drug, and used for magnetohydrodynamic thermochemotherapy of different tumors. The placement of the tumors in an AC magnetic field led to hyperthermia at 46 degrees C for 30 min. In combination with tumor slime aspiration, a 30% regression of similar to 130 mm(3) non-metastatic P388 tumors in BDF1 mice was reached, together with a life span increase of 290%. The same procedure associated with cyclophosphamide treatment of similar to 500 mm(3) metastases tumor increased the animal's life span by 180%. (C) 2006 Elsevier B.V. All rights reserved.

引用

页码：176 / 180

页数：5

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