A new amoxicillin/clavulanate therapeutic system: Preparation, in vitro and pharmacokinetic evaluation

被引：13

作者：

Kerc, Janez ^{[1
]}

Opara, Jerneja ^{[1
]}

机构：

[1] Lek Pharmaceut DD, Sandoz Dev Ctr Slovenia, Ljubljana 1526, Slovenia

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2007年 / 335卷 / 1-2期

关键词：

amoxicillin; clavulanate; therapeutic system; floating capsule; in vitro study; pharmacokinetic study;

D O I：

10.1016/j.ijpharm.2006.11.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A new peroral amoxicillin/clavulanate therapeutic system composed of immediate release tablet and controlled release floating capsule was developed and evaluated by in vivo bioavailability study. Pharmacokinetic (PK) parameters for amoxicillin and clavulanic acid of the new therapeutic systems: AUCt, AUCi, (AUCt/AUCi), Cmax, Tmax, kel, T-1/2 and additionally for amoxicillin T-4 and T-2 were calculated from the plasma levels. The study confirmed enhanced pharmacokinetic parameters of a newly developed therapeutic system containing 1500 mg of amoxicillin and 125 mg of clavulanic acid. Prolonged time over MIC of amoxicillin in relation to a regular immediate release amoxicillin/clavulanate formulation was confirmed. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：106 / 113

页数：8

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