Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins

被引：144

作者：

Seward, David J. ^{[1
]}

Cubberley, Gabrielle ^{[1
]}

Kim, Soojin ^{[1
]}

Schonewald, Matt ^{[1
]}

Zhang, Lian ^{[1
]}

Tripet, Brian ^{[1
]}

Bentley, David L. ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Sch Med, Dept Biochem & Mol Genet, Aurora, CO 80045 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 03期

关键词：

D O I：

10.1038/nsmb1200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone H3 Lys4 trimethylation (H3-K4me3) is a conserved mark of actively transcribed chromatin. Using a conditional mutant of the yeast H3-K4 methyltransferase, Set1p, we demonstrate rapid turnover of H3-K4me3 and H3-K4me2 in vivo and show this process requires Yjr119Cp, of the JARID1 family of JmjC proteins. Ectopic overexpression of mouse Jarid1B, a Yjr119Cp homolog, greatly diminished H3-K4me3 and H3-K4me2 in HeLa cells, suggesting these proteins function as K4 demethylases in vivo.

引用

页码：240 / 242

页数：3

共 18 条

[1] Structural insights into histone demethylation by JMJD2 family members [J].

Chen, Zhongzhou ;

Zang, Jianye ;

Whetstine, Johnathan ;

Hong, Xia ;

Davrazou, Foteini ;

Kutateladze, Tatiana G. ;

Simpson, Michael ;

Mao, Qilong ;

Pan, Cheol-Ho ;

Dai, Shaodong ;

Hagman, James ;

Hansen, Kirk ;

Shi, Yang ;

Zhang, Gongyi .

CELL, 2006, 125 (04) :691-702

[2] The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3 [J].

Cloos, Paul A. C. ;

Christensen, Jesper ;

Agger, Karl ;

Maiolica, Alessio ;

Rappsilber, Juri ;

Antal, Torben ;

Hansen, Klaus H. ;

Helin, Kristian .

NATURE, 2006, 442 (7100) :307-311

[3] Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation [J].

Jensen, LR ;

Amende, M ;

Gurok, U ;

Moser, B ;

Gimmel, V ;

Tzschach, A ;

Janecke, AR ;

Tariverdian, G ;

Chelly, J ;

Fryns, JP ;

Van Esch, H ;

Kleefstra, T ;

Hamel, B ;

Moraine, C ;

Gécz, J ;

Turner, G ;

Reinhardt, R ;

Kalscheuer, VM ;

Ropers, HH ;

Lenzner, S .

AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 76 (02) :227-236

[4] JmjC-domain-containing proteins and histone demethylation [J].

Klose, Robert J. ;

Kallin, Eric M. ;

Zhang, Yi .

NATURE REVIEWS GENETICS, 2006, 7 (09) :715-727

[5] A novel gene (PLU-1) containing highly conserved putative DNA chromatin binding motifs is specifically up-regulated in breast cancer [J].

Lu, PJ ;

Sundquist, K ;

Baeckstrom, D ;

Poulsom, R ;

Hanby, A ;

Meier-Ewert, S ;

Jones, T ;

Mitchell, M ;

Pitha-Rowe, P ;

Freemont, P ;

Taylor-Papadimitriou, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (22) :15633-15645

[6] Targeted recruitment of set1 histone methylase by elongating pol II provides a localized mark and memory of recent transcriptional activity [J].

Ng, HH ;

Robert, F ;

Young, RA ;

Struhl, K .

MOLECULAR CELL, 2003, 11 (03) :709-719

[7] A protein with similarity to the human retinoblastoma binding protein 2 acts specifically as a repressor for genes regulated by the b mating type locus in Ustilago maydis [J].

Quadbeck-Seeger, C ;

Wanner, G ;

Huber, S ;

Kahmann, R ;

Kämper, J .

MOLECULAR MICROBIOLOGY, 2000, 38 (01) :154-166

[8] Histone H3 lysine 4 methylation patterns in higher eukaryotic genes [J].

Schneider, R ;

Bannister, AJ ;

Myers, FA ;

Thorne, AW ;

Crane-Robinson, C ;

Kouzarides, T .

NATURE CELL BIOLOGY, 2004, 6 (01) :73-77

[9] Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1 [J].

Shi, YJ ;

Lan, F ;

Matson, C ;

Mulligan, P ;

Whetstine, JR ;

Cole, PA ;

Casero, RA ;

Shi, Y .

CELL, 2004, 119 (07) :941-953

[10] Chromatin modifications by methylation and ubiquitination: Implications in the regulation of gene expression [J].

Shilatifard, Ali .

ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 :243-269

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