Expression of A New Endogenous Retrovirus-Associated Transcript in Hodgkin Lymphoma Cells

被引：3
|
作者：
Schneider, Jana [1 ]
Volkmer, Ines [1 ]
Engel, Kristina [1 ]
Emmer, Alexander [2 ]
Staege, Martin S. [1 ]
机构：
[1] Martin Luther Univ Halle Wittenberg, Dept Surg & Conservat Pediat & Adolescent Med, D-06097 Halle, Germany
[2] Martin Luther Univ Halle Wittenberg, Dept Neurol, D-06097 Halle, Germany
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 21期
关键词：
Hodgkin lymphoma; gene expression; colony stimulating factor 1 (CSF1); endogenous retrovirus (ERV); LTR8; PRIMITIVE NEUROECTODERMAL TUMOR; EPSTEIN-BARR-VIRUS; SPECIES-SPECIFICITY; GENOME BROWSER; LINES; GENE; DISEASE; ESTABLISHMENT; PROLIFERATION; PATHOGENESIS;
D O I：
10.3390/ijms20215320
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
During characterization of a cDNA library from the Hodgkin lymphoma (HL) cell line L-1236, we discovered a new transcript derived from chromosome 1 at the long intergenic non-protein coding RNA 1768 (LINC01768)/colony stimulating factor 1 (CSF1) region. The first exon of this transcript from Hodgkin lymphoma cells (THOLE) starts in the predicted exon 4 of LINC01768 and is part of an endogenous retrovirus (ERV) from the HUERS-P1/LTR8 family. High expression of THOLE was only detectable in HL cell line L-1236. The expression of THOLE in L-1236 cell is another example for ERV/LTR-associated gene expression in HL cells. At the genome level, the HUERS-P1/LTR8 region including THOLE is only present in Hominoidea. The influence of ERV/LTRs on gene expression might explain the characteristic phenotype of human HL.
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页数：11
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