Atopic dermatitis: the role of Langerhans cells in disease pathogenesis

被引：56
作者：
Dubrac, Sandrine [1 ]
Schmuth, Matthias [1 ]
Ebner, Susanne [1 ,2 ]
机构：
[1] Innsbruck Med Univ, Dept Dermatol & Venereol, A-6020 Innsbruck, Austria
[2] K1 Ctr Oncotyrol, Innsbruck, Austria
来源：
IMMUNOLOGY AND CELL BIOLOGY | 2010年 / 88卷 / 04期
关键词：
atopic dermatitis; Langerhans cells; mouse models; TSLP; Fc epsilon RI; TSLPR; FC-EPSILON-RI; THYMIC STROMAL LYMPHOPOIETIN; ANTIGEN-PRESENTING CELLS; REGULATORY T-CELLS; INFLAMMATORY SKIN DISEASES; EPIDERMAL DENDRITIC CELLS; HIGH-AFFINITY RECEPTOR; DS-NH MICE; NC/NGA MICE; ALLERGEN PRESENTATION;
D O I：
10.1038/icb.2010.33
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The manifestation of atopic dermatitis (AD) results from a complex interaction of environmental factors, skin barrier defects and immunological phenomena. The initial events in AD remain unclear while much progress has been made in identifying the mechanisms leading to the manifestation and maintenance of allergic inflammation. AD pathogenesis can be approached from many different points of view. In this review, we describe findings in mouse models and in humans separately. We focus on recent findings that underscore the importance of Langerhans cells in initial mechanisms of skin inflammation in AD. Immunology and Cell Biology (2010) 88, 400-409; doi: 10.1038/icb.2010.33; published online 30 March 2010
引用
收藏
页码：400 / 409
页数：10
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