Studies on core-shell structural nano-micelles based on star block copolymer of poly(lactide) and poly(2-(dimethylamino)ethyl methacrylate)

被引：14

作者：

Ni, Caihua ^{[1
]}

Zhu, Guangjun ^{[1
]}

Zhu, Changping ^{[2
]}

Yao, Bolong ^{[1
]}

Kumar, D. N. T. ^{[3
]}

机构：

[1] Jiangnan Univ, Sch Chem & Mat Engn, Wuxi 214122, Peoples R China

[2] Hohai Univ, Coll Comp & Informat Engn, Changzhou 213000, Peoples R China

[3] Jiangnan Univ, Key Lab Ecotext, Fiber Composite Res Ctr, Minist Educ, Wuxi 214122, Peoples R China

来源：

COLLOID AND POLYMER SCIENCE | 2010年 / 288卷 / 10-11期

基金：

中国国家自然科学基金;

关键词：

Nano-micelle; Star copolymer; Silsesquixane; Inorganic/polymer hybrid; TRANSFER RADICAL POLYMERIZATION; DRUG-RELEASE; NANOPARTICLES; DENDRIMERS; POLYMERS; KINETICS; WATER;

D O I：

10.1007/s00396-010-2250-6

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Inorganic/polymer hybrid star-shaped block copolymer nano-micelles were synthesized. In the synthetic route, multi-hydroxyl polyhedral oligomeric silsequioxane(POSS-(OH)(32)) was employed as the starting molecule to initiate ring-opening polymerization of d,l-lactide. 2-(Dimethylamino)ethyl methacrylate was found to polymerize at the end of polylactic acid chains, following mechanism of atom transfer radical polymerization. The well-defined star block copolymer core-shell nano-micelles were finally obtained. The structures of the copolymer and the micelles were characterized extensively. The micelles exhibited a regular spherical shape with an average diameter of 170 nm which was confirmed by transmission electron microscopy and dynamic laser scattering. The sizes of both the core and the shell were controlled by adjusting the feed ratios during the syntheses. The micelles demonstrated pH- and temperature-sensitive behaviors.

引用

页码：1193 / 1200

页数：8

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