Anti-prediabetic effect of rose hip (Rosa canina) extract in spontaneously diabetic Torii rats

BACKGROUNDPrediabetes, a high-risk state for developing diabetes showing impaired glucose tolerance but a normal fasting blood glucose level, has an increasing prevalence worldwide. However, no study investigating the prevention of impaired glucose tolerance at the prediabetic stage by anti-diabetic functional foods has been reported. Thus, the present study aimed to evaluate the anti-prediabetic effect of rose hip in a prediabetic rat model. RESULTSSpontaneously diabetic Torii (SDT) rats were supplemented with hot-water extract of rose hip at a dose of 100mgkg(-1) body weightday(-1) for 12weeks. The results obtained showed that the supplementation of rose hip extract improved impaired glucose tolerance, promoted insulin secretion, preserved pancreatic beta-cell function and suppressed plasma advanced glycation end-products formation of methylglyoxal-derived hydroimidazolone (MG-H1) residue and N-E-carboxymethyl-lysine residues (e.g. MG-H1, control: 465.543.8 versus rose hip: 59.1 +/- 13.0 pmolmgprotein(-1), P < 0.05) in SDT rats at the prediabetic stage (12-20weeks old). CONCLUSION The present study provides the first evidence showing that a hot-water extract of rose hip could exert an anti-prediabetic effect in a rat model. (c) 2017 Society of Chemical Industry