Safety of Food Oral Immunotherapy What We Know, and What We Need to Learn

被引：14

作者：

Vazquez-Cortes, Sonia ^{[1
]}

Jaqueti, Paloma ^{[2
]}

Arasi, Stefania ^{[3
]}

Machinena, Adrianna ^{[4
]}

Alvaro-Lozano, Montserrat ^{[4
]}

Fernandez-Rivas, Montserrat ^{[5
]}

机构：

[1] Hosp Clin San Carlos, IdISSC, ARADyAL, Allergy Dept, Prof Martin Lagos S-N, Madrid 28040, Spain

[2] Hosp Clin San Carlos, IdISSC, Allergy Dept, Prof Martin Lagos S-N, Madrid 28040, Spain

[3] IRCCS, Bambino Gesu Childrens Res Hosp, Dept Pediat Med, Pediat Allergol Unit, Piazza S Onofrio, I-00161 Rome, Italy

[4] Hosp St Joan de Deu, Allergy & Clin Immunol Dept, Seccio Al Lergia & Immunol Clin, Passeig St de Joan Deu, Barcelona 08590, Spain

[5] Hosp Clin San Carlos, Med UCM, IdISSC, Allergy Dept,ARADyAL, Prof Martin Lagos S-N, Madrid 28040, Spain

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2020年 / 40卷 / 01期

关键词：

Allergy; Food; Immunotherapy; Oral immunotherapy; Safety; COWS MILK ALLERGY; DOUBLE-BLIND; TOLERANCE INDUCTION; EGG ALLERGY; SUSTAINED UNRESPONSIVENESS; PREDICT SAFETY; HENS EGG; CHILDREN; DESENSITIZATION; IGE;

D O I：

10.1016/j.iac.2019.09.013

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Oral immunotherapy (OIT) for food allergy entails a risk of adverse reactions, including anaphylaxis. This safety concern is the major barrier for OIT to become a therapeutic option in clinical practice. The high heterogeneity in safety reporting of OIT studies prevents setting the safety profile accurately. An international consensus is needed to facilitate the analysis of large pooled clinical data with homogeneous safety reporting, that together with integrated omics, and patients/families' opinions, may help stratify the patients' risk and needs, and help developing safe(r) individualized care pathways. This will give OIT the right place in the food allergy therapy.

引用

页码：111 / +

页数：24

共 71 条

[1]

[Anonymous], 2019, J ALLERGY CLIN IMMUN

[2]

[Anonymous], 2019, J ALLERGY CLIN IMMUN

[3]

[Anonymous], J ALLERGY CLIN IMMUN

[4] The safety of oral immunotherapy for food allergy during maintenance phase: Effect of counselling on adverse reactions [J].

Arasi, Stefania ;

Caminiti, Lucia ;

Crisafulli, Giuseppe ;

Panasiti, Ilenia ;

Barbalace, Andrea ;

Passalacqua, Giovanni ;

Pajno, Giovanni Battista .

WORLD ALLERGY ORGANIZATION JOURNAL, 2019, 12 (01)

[5] Efficacy and Safety of AR101 in Oral Immunotherapy for Peanut Allergy: Results of ARC001, a Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial [J].

Bird, J. Andrew ;

Spergel, Jonathan M. ;

Jones, Stacie M. ;

Rachid, Rima ;

Assa'ad, Amal H. ;

Wang, Julie ;

Leonard, Stephanie A. ;

Laubach, Susan S. ;

Kim, Edwin H. ;

Vickery, Brian P. ;

Davis, Benjamin P. ;

Heimall, Jennifer ;

Cianferoni, Antonella ;

MacGinnitie, Andrew J. ;

Crestani, Elena ;

Burks, A. Wesley .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2018, 6 (02) :476-+

[6] Efficacy, Safety, and Quality of Life in a Multicenter, Randomized, Placebo-Controlled Trial of Low-Dose Peanut Oral Immunotherapy in Children with Peanut Allergy [J].

Blumchen, Katharina ;

Trendelenburg, Valerie ;

Ahrens, Frank ;

Gruebl, Armin ;

Hamelmann, Eckard ;

Hansen, Gesine ;

Heinzmann, Andrea ;

Nemat, Katja ;

Holzhauser, Thomas ;

Roeder, Martin ;

Rosenfeld, Leonard ;

Hartmann, Oliver ;

Niggemann, Bodo ;

Beyer, Kirsten .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2019, 7 (02) :479-+

[7] Oral Immunotherapy for Treatment of Egg Allergy in Children [J].

Burks, A. Wesley ;

Jones, Stacie M. ;

Wood, Robert A. ;

Fleischer, David M. ;

Sicherer, Scott H. ;

Lindblad, Robert W. ;

Stablein, Donald ;

Henning, Alice K. ;

Vickery, Brian P. ;

Liu, Andrew H. ;

Scurlock, Amy M. ;

Shreffler, Wayne G. ;

Plaut, Marshall ;

Sampson, Hugh A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (03) :233-243

[8] Oral Immunotherapy for Egg Allergy: A Double-Blind Placebo-Controlled Study, with Postdesensitization Follow-Up [J].

Caminiti, Lucia ;

Pajno, Giovanni B. ;

Crisafulli, Giuseppe ;

Chiera, Fernanda ;

Collura, Mirella ;

Panasci, Girolamo ;

Ruggeri, Paolo ;

Guglielmo, Francesco ;

Passalacqua, Giovanni .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2015, 3 (04) :532-539

[9] A new protocol for specific oral tolerance induction in children with IgE-mediated cow's milk allergy [J].

Caminiti, Lucia ;

Passalacqua, Giovanni ;

Barberi, Salvatore ;

Vita, Daniela ;

Barberio, Giovanni ;

De Luca, Raffaele ;

Pajno, Giovanni Battista .

ALLERGY AND ASTHMA PROCEEDINGS, 2009, 30 (04) :443-448

[10] Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety [J].

Chu, Derek K. ;

Wood, Robert A. ;

French, Shannon ;

Fiocchi, Alessandro ;

Jordana, Manel ;

Waserman, Susan ;

Brozek, Jan L. ;

Schuenemann, Holger J. .

LANCET, 2019, 393 (10187) :2222-2232

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