Recombinant HDL-like nanoparticles: A specific contrast agent for MRI of atherosclerotic plaques

被引：252
作者：
Frias, JC
Williams, KJ
Fisher, EA [1 ]
Fayad, ZA
机构：
[1] Mt Sinai Sch Med, Imaging Sci Labs, Dept Radiol, New York, NY USA
[2] Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, New York, NY USA
[3] CUNY, Sch Med, New York, NY 10029 USA
[4] Thomas Jefferson Univ, Philadelphia, PA 19107 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 50期
关键词：
D O I：
10.1021/ja044911a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new contrast agent for MRI based on recombinant HDL-like nanoparticles has been prepared. It shows a great potential as a contrast agent for atherosclerotic plaques in a relative short time (24 h post-injection) as it is selective for the plaques and is an endogenous molecule. It also can distinguish between different types of plaques as the enhancement obtained is different, depending on plaque composition. Copyright © 2004 American Chemical Society.
引用
收藏
页码：16316 / 16317
页数：2
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