Strategies and challenges for the next generation of therapeutic antibodies

被引：636
|
作者：
Beck, Alain [1 ]
Wurch, Thierry [1 ]
Bailly, Christian [1 ]
Corvaia, Nathalie [1 ]
机构：
[1] CIPF, F-74160 St Julien En Genevois, France
来源：
NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 05期
关键词：
MONOCLONAL-ANTIBODIES; CANCER-THERAPY; COLORECTAL-CANCER; DRUG; GLYCOSYLATION; BINDING; MOUSE; IDENTIFICATION; OPTIMIZATION; SPECIFICITY;
D O I：
10.1038/nri2747
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antibodies and related products are the fastest growing class of therapeutic agents. By analysing the regulatory approvals of IgG-based biotherapeutic agents in the past 10 years, we can gain insights into the successful strategies used by pharmaceutical companies so far to bring innovative drugs to the market. Many challenges will have to be faced in the next decade to bring more efficient and affordable antibody-based drugs to the clinic. Here, we discuss strategies to select the best therapeutic antigen targets, to optimize the structure of IgG antibodies and to design related or new structures with additional functions.
引用
收藏
页码：345 / 352
页数：8
相关论文
共 50 条
  • [1] Potelligent Antibodies as Next Generation Therapeutic Antibodies
    Shitara, Kenya
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2009, 129 (01): : 3 - 9
  • [2] Non-fucosylated Therapeutic Antibodies: The Next Generation of Therapeutic Antibodies
    Satoh, Mitsuo
    Iida, Shigeru
    Yamane-Ohnuki, Naoko
    Mori, Katsuhiro
    Kanda, Yutaka
    Kuni-Kamochi, Reiko
    Nakano, Ryosuke
    Imai-Nishiya, Harue
    Okazaki, Akira
    Shinkawa, Toyohide
    Natsume, Akihito
    Niwa, Rinpei
    Shitara, Kenya
    ANIMAL CELL TECHNOLOGY: BASIC AND APPLIED ASPECTS, VOL 15, 2009, 15 : 1 - +
  • [3] Strategies and challenges for the next generation of antibody drug conjugates
    Beck, Alain
    Goetsch, Liliane
    Dumontet, Charles
    Corvaia, Nathalie
    NATURE REVIEWS DRUG DISCOVERY, 2017, 16 (05) : 315 - 337
  • [4] Nonclinical Evaluation of Next-generation Therapeutic Monoclonal Antibodies
    Ishii-Watabe, Akiko
    Tada, Minoru
    Suzuki, Takuo
    Kawasaki, Nana
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2015, 135 (07): : 857 - 866
  • [5] A novel platform to produce human monoclonal antibodies The next generation of therapeutic human monoclonal antibodies discovery
    Duvall, Marcus
    Bradley, Norma
    Fiorini, Ryan N.
    MABS, 2011, 3 (02) : 203 - 208
  • [6] Using phosphoproteomics and next generation sequencing to discover novel therapeutic targets in patient antibodies
    Zeneyedpour, Lona
    Sten-vant Hoff, Jenny
    Luider, Theo
    EXPERT REVIEW OF PROTEOMICS, 2020, 17 (09) : 675 - 684
  • [7] Antibacterial monoclonal antibodies: the next generation?
    DiGiandomenico, Antonio
    Sellman, Bret R.
    CURRENT OPINION IN MICROBIOLOGY, 2015, 27 : 78 - 85
  • [8] Fc Engineering Strategies to Advance IgA Antibodies as Therapeutic Agents
    van Tetering, Geert
    Evers, Mitchell
    Chan, Chilam
    Stip, Marjolein
    Leusen, Jeanette
    ANTIBODIES, 2020, 9 (04) : 1 - 15
  • [9] Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy
    Mimura, Yusuke
    Katoh, Toshihiko
    Saldova, Radka
    O'Flaherty, Roisin
    Izumi, Tomonori
    Mimura-Kimura, Yuka
    Utsunomiya, Toshiaki
    Mizukami, Yoichi
    Yamamoto, Kenji
    Matsumoto, Tsuneo
    Rudd, Pauline M.
    PROTEIN & CELL, 2018, 9 (01) : 47 - 62
  • [10] Next generation sequencing in epigenetics: Insights and challenges
    Meaburn, Emma
    Schulz, Reiner
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2012, 23 (02) : 192 - 199
12345