Peroxiredoxin: a central player in immune modulation

被引：95

作者：

Robinson, M. W. ^{[2
]}

Hutchinson, A. T. ^{[2
]}

Dalton, J. P. ^{[3
]}

Donnelly, S. ^{[1
,2
]}

机构：

[1] Natl Univ Ireland Maynooth, Dept Biol, Maynooth, Kildare, Ireland

[2] Univ Technol Sydney, IBID, Sydney, NSW 2007, Australia

[3] McGill Univ, Inst Parasitol, Ste Anne De Bellevue, PQ, Canada

来源：

PARASITE IMMUNOLOGY | 2010年 / 32卷 / 05期

关键词：

helminth; immunomodulation; macrophage; peroxiredoxin; ALTERNATIVELY ACTIVATED MACROPHAGES; EXCRETORY-SECRETORY PRODUCTS; ANTIGEN-PRESENTING CELLS; DRIVES TH2 RESPONSES; THIOREDOXIN PEROXIDASE; SCHISTOSOMA-MANSONI; BRUGIA-MALAYI; FASCIOLA-HEPATICA; ANTIOXIDANT ENZYME; HYDROGEN-PEROXIDE;

D O I：

10.1111/j.1365-3024.2010.01201.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

P>Peroxiredoxins (Prx) are a family of anti-oxidants that protect cells from metabolically produced reactive oxygen species (ROS). The presence of these enzymes in the secretomes of many parasitic helminths suggests they provide protection against ROS released by host immune effector cells. However, we recently reported that helminth-secreted Prx also contribute to the development of Th2-responses via a mechanism involving the induction of alternatively activated macrophages. In this review, we discuss the role helminth Prx may play in modulating the immune responses of their hosts.

引用

页码：305 / 313

页数：9

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