Two New Homoisoflavonoids from the Bulbs of Bessera elegans

被引：0

作者：

Matsuo, Yukiko ^{[1
]}

Kurihara, Risa ^{[1
]}

Akagi, Nana ^{[1
]}

Mimaki, Yoshihiro ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Tokyo 1920392, Japan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2014年 / 9卷 / 12期

关键词：

Bessera elegans; Liliaceae; Scillascillin-type; Homoisoflavonoid; HL-60; cells; TIG-3;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A further chemical investigation of the bulbs of Bessera elegans (Liliaceae) led to the isolation of a new homoisoflavonoid (1), a new scillascillin-type homoisoflavonoid (2), three known flavonoids (3-5), and two known norlignans (6 and 7). The structures of the new homoisoflavonoids (1 and 2) were determined based on the results of extensive spectroscopic analysis, including two-dimensional NMR data. The isolated compounds (1-7) were evaluated for cytotoxicity against HL-60 human promyelocytic leukemia cells and TIG-3 normal human diploid fibroblasts. Compound 1 exhibited potent tumor-selective cytotoxic activity against HL-60 cells.

引用

页码：1725 / 1727

页数：3

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