Large-scale biotechnological production of the antileukemic marine natural product sorbicillactone

被引：14

作者：

Bringmann, Gerhard

Gulder, Tobias A. M.

Lang, Gerhard

Stefanie, Schmitt

Stoehr, Ruediger

Wiese, Jutta

Nagel, Kerstin

Imhoff, Johannes F.

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[2] IFM, GEOMAR, Leibniz Inst Meereswissensch, D-24105 Kiel, Germany

来源：

MARINE DRUGS | 2007年 / 5卷 / 02期

关键词：

sorbicillactone A; anti-leukemic activity; large-scale production; BIOTECmarin;

D O I：

10.3390/md20070003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the search for novel bioactive compounds from sponge-derived microorganisms, we have recently identified two structurally and biosynthetically unprecedented fungal metabolites, the novel-type alkaloids sorbicillactone A and sorbicillactone B. Sorbicillactone A is active against leukemia cells without showing notable cytotoxicity. Therefore, we have developed an efficient process for its biotechnological production and isolation on a large scale supplying sufficient material for the ongoing preclinical investigations and structure-activity relationship (SAR) studies.

引用

页码：23 / 30

页数：8

共 7 条

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Stöhr, R ;

Wiese, J ;

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