Synthesis of new sugar derivatives from Stachys sieboldi Miq and antibacterial evaluation against Mycobacterium tuberculosis, Mycobacterium avium, and Staphylococcus aureus

被引：9

作者：

Chiba, Taku

Takii, Takemasa ^{[1
]}

Nishimura, Kenji

Yamamoto, Yoshifumi

Morikawa, Hiroko

Abe, Chiyoji

Onozaki, Kikuo

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Dept Mol Hlth Sci, Nagoya, Aichi, Japan

[2] Kinjo Gokuin Univ, Coll Pharm, Nagoya, Aichi, Japan

[3] Japan Anti Tuberculosis Assoc, Res Inst Tuberculosis, Tokyo, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 09期

基金：

日本学术振兴会;

关键词：

stachyose; beta-allyl manninotrioside; antibacterial activity;

D O I：

10.1016/j.bmcl.2007.02.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of sugar derivatives (7-14) were synthesized from stachyose, a sugar compound of Stachys sieboldi Miq, and evaluated for antibacterial activity against Mycobacterium tuberculosis, Mycobacterium avium, and Staphylococcus aureus, and their structure-activity relationships were studied. The results showed that the compound OCT359 (allyl O-(2,3,4,6-tetra-O-acetyl-alpha-D-galactopyranosyl)-(1 6)-O-(2,3,4-tri-O-acetyl-alpha-D-galactopyranosyl)-(1 -> 6)-O-2,3,4-tri-O-acetyl-alpha-D-glucopyranoside) (12) exhibited in vitro antibacterial activity. The allyl group at C-1 and the acetoxy groups of the manninotrioside were requisite for the antibacterial activity. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2487 / 2491

页数：5

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