Residual Dipolar Couplings (RDCs) Analysis of Small Molecules Made Easy: Fast and Tuneable Alignment by Reversible Compression/Relaxation of Reusable PMMA Gels

被引：90

作者：

Gayathri, Chakicherla ^{[1
]}

Tsarevsky, Nicolay V. ^{[2
]}

Gil, Roberto R. ^{[1
]}

机构：

[1] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA

[2] ATRP Solut Inc, Pittsburgh, PA 15213 USA

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 12期

关键词：

gels; NMR spectroscopy; residual dipolar couplings; small molecules; stereochemistry; ORIENTATIONAL PROPERTIES; ORGANIC-MOLECULES; NMR; MEDIA; ASSIGNMENT; SOLVENTS; ORDER; TOOL; STEREOCHEMISTRY; GUAIANOLIDES;

D O I：

10.1002/chem.200903378

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tuneable RDCs: A fast and tunable method for measuring anisotropic NMR parameters using variable compression/relaxation of clean and reusable PMMA gels in CDCl3 is introduced (see picture). No special devices are needed. The configuration and conformation of small molecules can be determined by using the RDC slopes without the need for performing a control experiment in isotropic conditions. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3622 / 3626

页数：5

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