Developmental changes of cardiac repolarization in rabbits: Implications for the role of sex hormones

被引:31
作者
Valverde, ER [1 ]
Biagetti, MO [1 ]
Bertran, GR [1 ]
Arini, PD [1 ]
Bidoggia, H [1 ]
Quinteiro, RA [1 ]
机构
[1] Favaloro Univ, Dept Physiol, Cardiac Electrophysiol Lab, RA-1078 Buenos Aires, DF, Argentina
关键词
ECG; gender; hormones; membrane potential; repolarization;
D O I
10.1016/S0008-6363(02)00791-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: Firstly, to compare gender-dependent differences of cardiac repolarization in both adult and young rabbits. Secondly, to analyze the effect of gonadectomy on these gender differences in cardiac repolarization. Methods: We evaluated potential gender differences in cardiac repolarization with both microelectrode and ECG recordings. QT(end), JT(end), and Tpeak-end intervals and action potential durations at 30%, 50% and 90% of full repolarization were used to assess ventricular repolarization in adult (normal and gonadectomized) and young rabbits of both sexes. Results: Adult rabbits exhibited clear gender-related differences in repolarization evidenced by significantly longer JT(end) and Tpeak-end intervals and significantly longer APD30, APD50 and APD90 in females. These gender-related differences in repolarization were absent in young rabbits and were abolished by gonadectomy. Conclusions: Developmental changes of repolarization are present in rabbits. These changes are in agreement with those reported in humans and may further support the role played by sex hormones in the modulation of cardiac repolarization. (C) 2003 European Society of Cardiology. Published by Elsevier Science B.V.. All rights reserved.
引用
收藏
页码:625 / 631
页数:7
相关论文
共 26 条
  • [1] Antzelevitch C, 1997, J ELECTROCARDIOL, V30, P168
  • [2] Effects of 17β-estradiol on action potentials and ionic currents in male rat ventricular myocytes
    Berger, F
    Borchard, U
    Hafner, D
    Pütz, I
    Weis, TM
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1997, 356 (06) : 788 - 796
  • [3] CHANGES IN THE TESTOSTERONE TO DIHYDROTESTOSTERONE RATIO IN PLASMA AND TESTES OF MATURING RABBITS
    BERGER, M
    CORRE, M
    JEANFAUCHER, C
    DETURCKHEIM, M
    VEYSSIERE, G
    JEAN, C
    [J]. ENDOCRINOLOGY, 1979, 104 (05) : 1450 - 1454
  • [4] TESTOSTERONE, LUTEINIZING-HORMONE (LH) AND FOLLICLE-STIMULATING-HORMONE (FSH) IN PLASMA OF RABBIT FROM BIRTH TO ADULTHOOD - CORRELATION WITH SEXUAL AND BEHAVIORAL-DEVELOPMENT
    BERGER, M
    JEANFAUCHER, C
    DETURCKHEIM, M
    VEYSSIERE, G
    BLANC, MR
    POIRIER, JC
    JEAN, C
    [J]. ACTA ENDOCRINOLOGICA, 1982, 99 (03): : 459 - 465
  • [5] Sex differences on the electrocardiographic pattern of cardiac repolarization: Possible role of testosterone
    Bidoggia, H
    Maciel, JP
    Capalozza, N
    Mosca, S
    Blaksley, EJ
    Valverde, E
    Bertran, G
    Arini, P
    Biagetti, MO
    Quinteiro, RA
    [J]. AMERICAN HEART JOURNAL, 2000, 140 (04) : 678 - 683
  • [6] Sex-dependent electrocardiographic pattern of cardiac repolarization
    Bidoggia, H
    Maciel, JP
    Capalozza, N
    Mosca, S
    Blaksley, EJ
    Valverde, E
    Bertran, G
    Arini, P
    Biagetti, MO
    Quinteiro, RA
    [J]. AMERICAN HEART JOURNAL, 2000, 140 (03) : 430 - 436
  • [7] Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel
    Deenadayalu, VUP
    White, RE
    Stallone, JN
    Gao, XM
    Garcia, AJ
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 281 (04): : H1720 - H1727
  • [8] CHANGES IN OVARIAN ESTROGENS AND IN PLASMA GONADOTROPINS IN FEMALE RABBITS FROM BIRTH TO ADULTHOOD
    DETURCKHEIM, M
    BERGER, M
    JEANFAUCHER, C
    VEYSSIERE, G
    JEAN, C
    [J]. ACTA ENDOCRINOLOGICA, 1983, 103 (01): : 125 - 130
  • [9] Testosterone-induced relaxation of rat aorta is androgen structure specific and involves K+ channel activation
    Ding, AQ
    Stallone, JN
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 2001, 91 (06) : 2742 - 2750
  • [10] Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart
    Drici, MD
    Burklow, TR
    Haridasse, V
    Glazer, RI
    Woosley, RL
    [J]. CIRCULATION, 1996, 94 (06) : 1471 - 1474