Scalability of photochemical reactions in continuous flow mode

被引:109
作者
Donnelly, Kian [1 ]
Baumann, Marcus [1 ]
机构
[1] Univ Coll Dublin, Sci Ctr South, Sch Chem, Dublin D04 N2E2, Ireland
关键词
Flow synthesis; Photochemistry; Scalability; Throughput; Continuous processing; BENZYLIC BROMINATION; STEREOSELECTIVE-SYNTHESIS; VERSATILE REACTOR; VORTEX REACTOR; PHOTOREDOX; SCALE; EFFICIENT; CATALYSIS; UV; CYCLIZATION;
D O I
10.1007/s41981-021-00168-z
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Continuous flow photochemistry as a field has witnessed an increasing popularity over the last decade in both academia and industry. Key drivers for this development are safety, practicality as well as the ability to rapidly access complex chemical structures. Continuous flow reactors, whether home-built or from commercial suppliers, additionally allow for creating valuable target compounds in a reproducible and automatable manner. Recent years have furthermore seen the advent of new energy efficient LED lamps that in combination with innovative reactor designs provide a powerful means to increasing both the practicality and productivity of modern photochemical flow reactors. In this review article we wish to highlight key achievements pertaining to the scalability of such continuous photochemical processes.
引用
收藏
页码:223 / 241
页数:19
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  • [1] Scalability of Visible-Light-Induced Nickel Negishi Reactions: A Combination of Flow Photochemistry, Use of Solid Reagents, and In-Line NMR Monitoring
    Abdiaj, Irini
    Horn, Clemens R.
    Alcazar, Jesus
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2019, 84 (08) : 4748 - 4753
  • [2] Visible-Light-Induced Nickel-Catalyzed Negishi Cross-Couplings by Exogenous-Photosensitizer-Free Photocatalysis
    Abdiaj, Irini
    Fontana, Alberto
    Gomez, M. Victoria
    de la Hoz, Antonio
    Alcazar, Jesus
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 57 (28) : 8473 - 8477
  • [3] Improving the throughput of batch photochemical reactions using flow: Dual photoredox and nickel catalysis in flow for C(sp2)-C(sp3) cross-coupling
    Abdiaj, Irini
    Alcazar, Jesus
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 25 (23) : 6190 - 6196
  • [4] Photochemical Reactions as Key Steps in Natural Product Synthesis
    Bach, Thorsten
    Hehn, Joerg P.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (05) : 1000 - 1045
  • [5] Photochemical Perfluoroalkylation with Pyridine N-Oxides: Mechanistic Insights and Performance on a Kilogram Scale
    Beatty, Joel W.
    Douglas, James J.
    Miller, Richard
    McAtee, Rory C.
    Cole, Kevin P.
    Stephenson, Corey R. J.
    [J]. CHEM, 2016, 1 (03): : 456 - 472
  • [6] A scalable and operationally simple radical trifluoromethylation
    Beatty, Joel W.
    Douglas, James J.
    Cole, Kevin P.
    Stephenson, Corey R. J.
    [J]. NATURE COMMUNICATIONS, 2015, 6
  • [7] Development and Execution of a Production-Scale Continuous [2+2] Photocycloaddition
    Beaver, Matthew G.
    Zhang, En-xuan
    Liu, Zhi-qing
    Zheng, Song-yuan
    Wang, Bin
    Lu, Jiang-ping
    Tao, Jian
    Gonzalez, Miguel
    Jones, Sian
    Tedrow, Jason S.
    [J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2020, 24 (10) : 2139 - 2146
  • [8] Scalable and robust photochemical flow process towards small spherical gold nanoparticles
    Bianchi, Pauline
    Petit, Guillaume
    Monbaliu, Jean-Christophe M.
    [J]. REACTION CHEMISTRY & ENGINEERING, 2020, 5 (07) : 1224 - 1236
  • [9] Rapid and Scalable Access into Strained Scaffolds through Continuous Flow Photochemistry
    Blanco-Ania, Daniel
    Gawade, Sagar Ashok
    Zwinkels, Luc J. L.
    Maartense, Luuk
    Bolster, Marjon G.
    Benningshof, Jorg C. J.
    Rutjes, Floris P. J. T.
    [J]. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2016, 20 (02) : 409 - 413
  • [10] Development of a Continuous Flow Photoisomerization Reaction Converting Isoxazoles into Diverse Oxazole Products
    Bracken, Cormac
    Baumann, Marcus
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2020, 85 (04) : 2607 - 2617