共 86 条
Scalability of photochemical reactions in continuous flow mode
被引:123
作者:

Donnelly, Kian
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h-index: 0
机构:
Univ Coll Dublin, Sci Ctr South, Sch Chem, Dublin D04 N2E2, Ireland Univ Coll Dublin, Sci Ctr South, Sch Chem, Dublin D04 N2E2, Ireland

Baumann, Marcus
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Coll Dublin, Sci Ctr South, Sch Chem, Dublin D04 N2E2, Ireland Univ Coll Dublin, Sci Ctr South, Sch Chem, Dublin D04 N2E2, Ireland
机构:
[1] Univ Coll Dublin, Sci Ctr South, Sch Chem, Dublin D04 N2E2, Ireland
关键词:
Flow synthesis;
Photochemistry;
Scalability;
Throughput;
Continuous processing;
BENZYLIC BROMINATION;
STEREOSELECTIVE-SYNTHESIS;
VERSATILE REACTOR;
VORTEX REACTOR;
PHOTOREDOX;
SCALE;
EFFICIENT;
CATALYSIS;
UV;
CYCLIZATION;
D O I:
10.1007/s41981-021-00168-z
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Continuous flow photochemistry as a field has witnessed an increasing popularity over the last decade in both academia and industry. Key drivers for this development are safety, practicality as well as the ability to rapidly access complex chemical structures. Continuous flow reactors, whether home-built or from commercial suppliers, additionally allow for creating valuable target compounds in a reproducible and automatable manner. Recent years have furthermore seen the advent of new energy efficient LED lamps that in combination with innovative reactor designs provide a powerful means to increasing both the practicality and productivity of modern photochemical flow reactors. In this review article we wish to highlight key achievements pertaining to the scalability of such continuous photochemical processes.
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页码:223 / 241
页数:19
相关论文
共 86 条
[1]
Scalability of Visible-Light-Induced Nickel Negishi Reactions: A Combination of Flow Photochemistry, Use of Solid Reagents, and In-Line NMR Monitoring
[J].
Abdiaj, Irini
;
Horn, Clemens R.
;
Alcazar, Jesus
.
JOURNAL OF ORGANIC CHEMISTRY,
2019, 84 (08)
:4748-4753

Abdiaj, Irini
论文数: 0 引用数: 0
h-index: 0
机构:
Janssen Cilag SA, Lead Discovery, Janssen Res & Dev, Jarama 75A, Toledo 45007, Spain Janssen Cilag SA, Lead Discovery, Janssen Res & Dev, Jarama 75A, Toledo 45007, Spain

Horn, Clemens R.
论文数: 0 引用数: 0
h-index: 0
机构:
Corning SAS, Corning European Technol Ctr, 7 Bis Ave Valvins,CS 70156, F-77215 Samois Sur Seine, Avon, France Janssen Cilag SA, Lead Discovery, Janssen Res & Dev, Jarama 75A, Toledo 45007, Spain

Alcazar, Jesus
论文数: 0 引用数: 0
h-index: 0
机构:
Janssen Cilag SA, Lead Discovery, Janssen Res & Dev, Jarama 75A, Toledo 45007, Spain Janssen Cilag SA, Lead Discovery, Janssen Res & Dev, Jarama 75A, Toledo 45007, Spain
[2]
Visible-Light-Induced Nickel-Catalyzed Negishi Cross-Couplings by Exogenous-Photosensitizer-Free Photocatalysis
[J].
Abdiaj, Irini
;
Fontana, Alberto
;
Gomez, M. Victoria
;
de la Hoz, Antonio
;
Alcazar, Jesus
.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,
2018, 57 (28)
:8473-8477

Abdiaj, Irini
论文数: 0 引用数: 0
h-index: 0
机构:
Janssen Cilag SA, Oncol & Discovery Chem, Janssen Res & Dev, Jarama 75A, Toledo 45007, Spain Janssen Cilag SA, Oncol & Discovery Chem, Janssen Res & Dev, Jarama 75A, Toledo 45007, Spain

Fontana, Alberto
论文数: 0 引用数: 0
h-index: 0
机构:
Janssen Cilag SA, Oncol & Discovery Chem, Janssen Res & Dev, Jarama 75A, Toledo 45007, Spain Janssen Cilag SA, Oncol & Discovery Chem, Janssen Res & Dev, Jarama 75A, Toledo 45007, Spain

Gomez, M. Victoria
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Castilla La Mancha, Fac Ciencias Quim, Av Camilo Jose Cela 14, Ciudad Real 13005, Spain Janssen Cilag SA, Oncol & Discovery Chem, Janssen Res & Dev, Jarama 75A, Toledo 45007, Spain

de la Hoz, Antonio
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Castilla La Mancha, Fac Ciencias Quim, Av Camilo Jose Cela 14, Ciudad Real 13005, Spain Janssen Cilag SA, Oncol & Discovery Chem, Janssen Res & Dev, Jarama 75A, Toledo 45007, Spain

Alcazar, Jesus
论文数: 0 引用数: 0
h-index: 0
机构:
Janssen Cilag SA, Oncol & Discovery Chem, Janssen Res & Dev, Jarama 75A, Toledo 45007, Spain Janssen Cilag SA, Oncol & Discovery Chem, Janssen Res & Dev, Jarama 75A, Toledo 45007, Spain
[3]
Improving the throughput of batch photochemical reactions using flow: Dual photoredox and nickel catalysis in flow for C(sp2)-C(sp3) cross-coupling
[J].
Abdiaj, Irini
;
Alcazar, Jesus
.
BIOORGANIC & MEDICINAL CHEMISTRY,
2017, 25 (23)
:6190-6196

Abdiaj, Irini
论文数: 0 引用数: 0
h-index: 0
机构:
Janssen Cilag SA, Janssen Res & Dev, C Jarama 75, Toledo 45007, Spain Janssen Cilag SA, Janssen Res & Dev, C Jarama 75, Toledo 45007, Spain

Alcazar, Jesus
论文数: 0 引用数: 0
h-index: 0
机构:
Janssen Cilag SA, Janssen Res & Dev, C Jarama 75, Toledo 45007, Spain Janssen Cilag SA, Janssen Res & Dev, C Jarama 75, Toledo 45007, Spain
[4]
Photochemical Reactions as Key Steps in Natural Product Synthesis
[J].
Bach, Thorsten
;
Hehn, Joerg P.
.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,
2011, 50 (05)
:1000-1045

Bach, Thorsten
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Munich, Lehrstuhl Organ Chem 1, D-85747 Garching, Germany Tech Univ Munich, Lehrstuhl Organ Chem 1, D-85747 Garching, Germany

Hehn, Joerg P.
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Munich, Lehrstuhl Organ Chem 1, D-85747 Garching, Germany Tech Univ Munich, Lehrstuhl Organ Chem 1, D-85747 Garching, Germany
[5]
Photochemical Perfluoroalkylation with Pyridine N-Oxides: Mechanistic Insights and Performance on a Kilogram Scale
[J].
Beatty, Joel W.
;
Douglas, James J.
;
Miller, Richard
;
McAtee, Rory C.
;
Cole, Kevin P.
;
Stephenson, Corey R. J.
.
CHEM,
2016, 1 (03)
:456-472

Beatty, Joel W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

Douglas, James J.
论文数: 0 引用数: 0
h-index: 0
机构:
Eli Lilly & Co, Lilly Res Labs, Small Mol Design & Dev, Indianapolis, IN 46285 USA Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

Miller, Richard
论文数: 0 引用数: 0
h-index: 0
机构:
Eli Lilly & Co, Lilly Res Labs, Small Mol Design & Dev, Indianapolis, IN 46285 USA Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

McAtee, Rory C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

Cole, Kevin P.
论文数: 0 引用数: 0
h-index: 0
机构:
Eli Lilly & Co, Lilly Res Labs, Small Mol Design & Dev, Indianapolis, IN 46285 USA Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

Stephenson, Corey R. J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
[6]
A scalable and operationally simple radical trifluoromethylation
[J].
Beatty, Joel W.
;
Douglas, James J.
;
Cole, Kevin P.
;
Stephenson, Corey R. J.
.
NATURE COMMUNICATIONS,
2015, 6

Beatty, Joel W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

Douglas, James J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
Eli Lilly & Co, Lilly Res Labs, Small Mol Design & Dev, Indianapolis, IN 46285 USA Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

Cole, Kevin P.
论文数: 0 引用数: 0
h-index: 0
机构:
Eli Lilly & Co, Lilly Res Labs, Small Mol Design & Dev, Indianapolis, IN 46285 USA Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

Stephenson, Corey R. J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
[7]
Development and Execution of a Production-Scale Continuous [2+2] Photocycloaddition
[J].
Beaver, Matthew G.
;
Zhang, En-xuan
;
Liu, Zhi-qing
;
Zheng, Song-yuan
;
Wang, Bin
;
Lu, Jiang-ping
;
Tao, Jian
;
Gonzalez, Miguel
;
Jones, Sian
;
Tedrow, Jason S.
.
ORGANIC PROCESS RESEARCH & DEVELOPMENT,
2020, 24 (10)
:2139-2146

Beaver, Matthew G.
论文数: 0 引用数: 0
h-index: 0
机构:
Amgen Inc, Proc Dev, Cambridge, MA 02142 USA Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China

Zhang, En-xuan
论文数: 0 引用数: 0
h-index: 0
机构:
Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China

Liu, Zhi-qing
论文数: 0 引用数: 0
h-index: 0
机构:
Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China

Zheng, Song-yuan
论文数: 0 引用数: 0
h-index: 0
机构:
Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China

Wang, Bin
论文数: 0 引用数: 0
h-index: 0
机构:
Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China

Lu, Jiang-ping
论文数: 0 引用数: 0
h-index: 0
机构:
Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China

Tao, Jian
论文数: 0 引用数: 0
h-index: 0
机构:
Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China

Gonzalez, Miguel
论文数: 0 引用数: 0
h-index: 0
机构:
Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China

Jones, Sian
论文数: 0 引用数: 0
h-index: 0
机构:
Amgen Inc, Proc Dev, Thousand Oaks, CA 91320 USA Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China

Tedrow, Jason S.
论文数: 0 引用数: 0
h-index: 0
机构:
Amgen Inc, Proc Dev, Cambridge, MA 02142 USA Asymchem Life Sci Tianjin Co Ltd, Tianjin 300457, Peoples R China
[8]
Scalable and robust photochemical flow process towards small spherical gold nanoparticles
[J].
Bianchi, Pauline
;
Petit, Guillaume
;
Monbaliu, Jean-Christophe M.
.
REACTION CHEMISTRY & ENGINEERING,
2020, 5 (07)
:1224-1236

Bianchi, Pauline
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liege, MolSys Res Unit, Ctr Integrated Technol & Organ Synth, B-4000 Liege, Sart Tilman, Belgium Univ Liege, MolSys Res Unit, Ctr Integrated Technol & Organ Synth, B-4000 Liege, Sart Tilman, Belgium

Petit, Guillaume
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liege, MolSys Res Unit, Ctr Integrated Technol & Organ Synth, B-4000 Liege, Sart Tilman, Belgium Univ Liege, MolSys Res Unit, Ctr Integrated Technol & Organ Synth, B-4000 Liege, Sart Tilman, Belgium

Monbaliu, Jean-Christophe M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Liege, MolSys Res Unit, Ctr Integrated Technol & Organ Synth, B-4000 Liege, Sart Tilman, Belgium Univ Liege, MolSys Res Unit, Ctr Integrated Technol & Organ Synth, B-4000 Liege, Sart Tilman, Belgium
[9]
Rapid and Scalable Access into Strained Scaffolds through Continuous Flow Photochemistry
[J].
Blanco-Ania, Daniel
;
Gawade, Sagar Ashok
;
Zwinkels, Luc J. L.
;
Maartense, Luuk
;
Bolster, Marjon G.
;
Benningshof, Jorg C. J.
;
Rutjes, Floris P. J. T.
.
ORGANIC PROCESS RESEARCH & DEVELOPMENT,
2016, 20 (02)
:409-413

Blanco-Ania, Daniel
论文数: 0 引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands

Gawade, Sagar Ashok
论文数: 0 引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands

Zwinkels, Luc J. L.
论文数: 0 引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands

Maartense, Luuk
论文数: 0 引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands

Bolster, Marjon G.
论文数: 0 引用数: 0
h-index: 0
机构:
Mercachem BV, Kerkenbos 1013, NL-6546 BB Nijmegen, Netherlands Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands

Benningshof, Jorg C. J.
论文数: 0 引用数: 0
h-index: 0
机构:
Mercachem BV, Kerkenbos 1013, NL-6546 BB Nijmegen, Netherlands Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands

Rutjes, Floris P. J. T.
论文数: 0 引用数: 0
h-index: 0
机构:
Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands
[10]
Development of a Continuous Flow Photoisomerization Reaction Converting Isoxazoles into Diverse Oxazole Products
[J].
Bracken, Cormac
;
Baumann, Marcus
.
JOURNAL OF ORGANIC CHEMISTRY,
2020, 85 (04)
:2607-2617

Bracken, Cormac
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Coll Dublin, Sch Chem, Dublin 4, Ireland Univ Coll Dublin, Sch Chem, Dublin 4, Ireland

Baumann, Marcus
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Coll Dublin, Sch Chem, Dublin 4, Ireland Univ Coll Dublin, Sch Chem, Dublin 4, Ireland