Substituted quinolinones.: Part 13 -: A convenient route to heterocyclization reactions with 3-substituted 4-hydroxyquinolin-2(1H)-one

被引：13
作者：
Abdel-Megid, Mohamed [1 ]
Abass, Mohamed [1 ]
Hassan, Mohamed [1 ]
机构：
[1] Ain Shams Univ, Dept Chem, Fac Educ, Cairo 11757, Egypt
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 44卷 / 02期
关键词：
D O I：
10.1002/jhet.5570440206
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reactivity of 3-[(dimethylamino)prop-2-enoyl]-4-hydroxyl-1-methylquinolin-2(1H)-one (2) towards different nucleophilic and electrophilic reagents was investigated. The convenient synthesis of several 3-heterocyclyl-quinolinones such, as 3-pyridazinyl- 10, 11, 3-pyranyl 19a,b and 3-pyrazolylquinolinones 20a,b, 22, 26a,b, 27a,b, 31 and 33 has been described starting from the 3-acetylquinolinone 1 and enaminone 2. In addition, certain heterocyclo[c]quinolinones such as pyrimido- 12, 14 pyrano- 3, 17a,b and pyrazolopyranoquinolinone 29 were obtained in good yields.
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收藏
页码：315 / 322
页数：8
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