Emerging Roles of Extracellular Vesicles in the Nervous System

被引:217
作者
Rajendran, Lawrence [1 ,2 ,3 ]
Bali, Jitin [1 ,2 ,3 ]
Barr, Maureen M. [4 ]
Court, Felipe A. [5 ,6 ]
Kramer-Albers, Eva-Maria [7 ,8 ]
Picou, Frederic [5 ]
Raposo, Graca [9 ,10 ]
van der Vos, Kristan E. [11 ]
van Nie, Guillaume [9 ,10 ]
Wang, Juan
Breakefield, Xandra O. [12 ,13 ,14 ]
机构
[1] Univ Zurich, Div Psychiat Res, CH-8006 Zurich, Switzerland
[2] Univ Zurich, Grad Sch, Zurich Neurosci Ctr, CH-8006 Zurich, Switzerland
[3] Univ Zurich, CH-8006 Zurich, Switzerland
[4] Rutgers State Univ, Dept Genet, Inst Human Genet, Piscataway, NJ 08854 USA
[5] Pontificia Univ Catolica Chile, Fac Biol, Millenium Nucl Regenerat Biol, Santiago, Chile
[6] Neurounion Biomed Fdn, Santiago, Chile
[7] Johannes Gutenberg Univ Mainz, Dept Mol Cell Biol, D-55122 Mainz, Germany
[8] Johannes Gutenberg Univ Mainz, Focus Programme Translat Neurosci, D-55122 Mainz, Germany
[9] Inst Curie, Ctr Rech, F-75248 Paris, France
[10] CNRS, Unite Mixte Rech 144, F-75248 Paris, France
[11] Netherlands Canc Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands
[12] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
[13] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA
[14] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02114 USA
基金
瑞士国家科学基金会; 美国国家卫生研究院;
关键词
TERMINAL FRAGMENT; SCHWANN-CELLS; EXOSOMES; PROTEIN; RNA; RELEASE; MECHANISMS; TRANSPORT; MEDIATORS; COMMUNICATION;
D O I
10.1523/JNEUROSCI.3258-14.2014
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Information exchange executed by extracellular vesicles, including exosomes, is a newly described form of intercellular communication important in the development and physiology of neural systems. These vesicles can be released from cells, are packed with information including signaling proteins and both coding and regulatory RNAs, and can be taken up by target cells, thereby facilitating the transfer of multilevel information. Recent studies demonstrate their critical role in physiological processes, including nerve regeneration, synaptic function, and behavior. These vesicles also have a sinister role in the propagation of toxic amyloid proteins in neurodegenerative conditions, including prion diseases and Alzheimer's and Parkinson's diseases, in inducing neuroinflammation by exchange of information between the neurons and glia, as well as in aiding tumor progression in the brain by subversion of normal cells. This article provides a summary of topics covered in a symposium and is not meant to be a comprehensive review of the subject.
引用
收藏
页码:15482 / 15489
页数:8
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