Remarkable effect of lithium salts in Friedel-Crafts acylation of 2-methoxynaphthalene catalyzed by metal triflates

被引：56

作者：

Kobayashi, S ^{[1
]}

Komoto, I ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON | 2000年 / 56卷 / 35期

关键词：

D O I：

10.1016/S0040-4020(00)00610-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of a catalytic amount of a metal triflate such as Sb(OTf)(3) or Ga(OTf)(3), 2-methoxynaphthalene reacted with acetic anhydride in nitromethane-lithium perchlorate to afford 2-acetyl-6-methoxynaphthalene, a well-known intermediate for the synthesis of naproxen, in a high yield. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：6463 / 6465

页数：3

共 27 条

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