Development of structure-function coupling in human brain networks during youth

被引：310

作者：

Baum, Graham L. ^{[1
,2
]}

Cui, Zaixu ^{[1
,2
]}

Roalf, David R. ^{[1
,2
]}

Ciric, Rastko ^{[3
]}

Betzel, Richard F. ^{[4
]}

Larsen, Bart ^{[1
,2
]}

Cieslak, Matthew ^{[1
,2
]}

Cook, Philip A. ^{[5
]}

Xia, Cedric H. ^{[1
,2
]}

Moore, Tyler M. ^{[1
,2
]}

Ruparel, Kosha ^{[1
,2
]}

Oathes, Desmond J. ^{[1
]}

Alexander-Bloch, Aaron F. ^{[6
]}

Shinohara, Russell T. ^{[7
,8
]}

Raznahan, Armin ^{[9
]}

Gur, Raquel E. ^{[1
,2
,5
,10
]}

Gur, Ruben C. ^{[1
,2
,5
,10
]}

Bassett, Danielle S. ^{[1
,10
,11
,12
,13
,14
]}

Satterthwaite, Theodore D. ^{[1
,2
]}

机构：

[1] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Lifespan Brain Inst, Philadelphia, PA 19104 USA

[3] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[4] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN 47405 USA

[5] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

[6] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06510 USA

[7] Univ Penn, Dept Biostat Epidemiol & Informat, Penn Stat Imaging & Visualizat Ctr, Philadelphia, PA 19104 USA

[8] Univ Penn, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA

[9] NIMH, Dev Neurogen Unit, Bethesda, MD 20814 USA

[10] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[11] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

[12] Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA

[13] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA

[14] Santa Fe Inst, Santa Fe, NM 87501 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2020年 / 117卷 / 01期

关键词：

brain development; MRI; connectome; cortical organization; structure-function; CONNECTIVITY; PATTERNS; SPECIALIZATION; ARCHITECTURE; PREDICTS; DEFAULT; IMPACT; MOTION; CORTEX;

D O I：

10.1073/pnas.1912034117

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The protracted development of structural and functional brain connectivity within distributed association networks coincides with improvements in higher-order cognitive processes such as executive function. However, it remains unclear how white-matter architecture develops during youth to directly support coordinated neural activity. Here, we characterize the development of structure-function coupling using diffusion-weighted imaging and n-back functional MRI data in a sample of 727 individuals (ages 8 to 23 y). We found that spatial variability in structure-function coupling aligned with cortical hierarchies of functional specialization and evolutionary expansion. Furthermore, hierarchy-dependent age effects on structure-function coupling localized to transmodal cortex in both cross-sectional data and a subset of participants with longitudinal data (n = 294). Moreover, structure-function coupling in rostrolateral prefrontal cortex was associated with executive performance and partially mediated age-related improvements in executive function. Together, these findings delineate a critical dimension of adolescent brain development, whereby the coupling between structural and functional connectivity remodels to support functional specialization and cognition.

引用

页码：771 / 778

页数：8

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