Functions of the two glutamate transporters GLAST and GLT-1 in the retina

被引：216

作者：

Harada, T

Harada, C

Watanabe, M

Inoue, Y

Sakagawa, T

Nakayama, N

Sasaki, S

Okuyama, S

Watase, K

Wada, K

Tanaka, K

机构：

[1] Natl Inst Neurosci, Dept Degenerat Neurol Dis, NCNP, Tokyo 1878502, Japan

[2] Hokkaido Univ, Dept Ophthalmol, Sch Med, Sapporo, Hokkaido 0608638, Japan

[3] Hokkaido Univ, Dept Anat, Sch Med, Sapporo, Hokkaido 0608638, Japan

[4] Taisho Pharmaceut Co Ltd, Toxicol Lab, Ohmiya, Saitama 3308530, Japan

[5] Taisho Pharmaceut Co Ltd, Pharmaceut Res Labs, Ohmiya, Saitama 3308530, Japan

[6] Taisho Pharmaceut Co Ltd, Lab 1, Med Res Labs, Ohmiya, Saitama 3308530, Japan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 08期

关键词：

D O I：

10.1073/pnas.95.8.4663

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the retina, the glutamate transporter GLAST is expressed in Muller cells, whereas the glutamate transporter GLT-1 is found only in cones and various types of bipolar cells. To investigate the functional role of this differential distribution of glutamate transporters, we have analyzed GLAST and GLT-1 mutant mice. In GLAST-deficient mice, the electroretinogram b-wave and oscillatory potentials are reduced and retinal damage after ischemia is exacerbated, whereas GLT-1-deficient mice show almost normal electroretinograms and mild increased retinal damage after ischemia, These results demonstrate that GLAST is required for normal signal transmission between photoreceptors and bipolar cells and that both GLAST and GLT-1 play a neuroprotective role during ischemia in the retina.

引用

页码：4663 / 4666

页数：4

共 29 条

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