Regulation of Tumor Metastasis by Myeloid-Derived Suppressor Cells

被引：395

作者：

Condamine, Thomas ^{[1
]}

Ramachandran, Indu ^{[1
]}

Youn, Je-In ^{[2
,3
]}

Gabrilovich, Dmitry I. ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

[2] Seoul Natl Univ, Coll Med, Wide River Inst Immunol, Hongcheon 250812, South Korea

[3] Seoul Natl Univ, Coll Med, Dept Med Sci, Seoul 110799, South Korea

来源：

ANNUAL REVIEW OF MEDICINE, VOL 66 | 2015年 / 66卷

关键词：

angiogenesis; tumor cell invasion; immune suppression; chemotherapy; COLONY-STIMULATING FACTOR; CANCER VACCINE; T-CELLS; IMMUNE SUPPRESSION; CARCINOMA PATIENTS; MELANOMA PATIENTS; CORRELATE; DIFFERENTIATION; RECRUITMENT; ACTIVATION;

D O I：

10.1146/annurev-med-051013-052304

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Accumulation of pathologically activated immature myeloid cells with potent immune-suppressive activity is one of the major immunological hallmarks of cancer. In recent years, it became clear that in addition to their immune-suppressive activity, myeloid-derived suppressor cells (MDSCs) influence tumor progression in a variety of ways. They are directly implicated in the promotion of tumor metastases by participating in the formation of premetastatic niches, promoting angiogenesis and tumor cell invasion. In this review, we discuss recent data describing various roles of MDSCs in the formation of tumor metastases.

引用

页码：97 / 110

页数：14

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