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Apoptosis in asymptomatic HIV-1 seropositives immunized with HIV-1 env glycoprotein (gp160): Effects of administration of Zidovudine in vivo and interleukin-2 in vitro
被引:3
|作者:
Pierdominici, M
Mollicone, B
Ricci, G
Oliva, A
D'Offizi, G
Giovannetti, A
Aiuti, F
Pandolfi, F
机构:
[1] Univ Roma La Sapienza, Chair Clin Immunol & Allergy, I-00185 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Chair Semeiot Med, I-00168 Rome, Italy
来源:
关键词:
D O I:
10.1016/S0264-410X(97)00251-X
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
In this paper we report the effects of VaxSyn(R) (Protein Sciences Corp.) immunization on spontaneous apoptosis ocurring in vitro after culture of PBMC in medium alone in 30 HIV-seropositive patients enrolled in a double-blind clinical trial that included three groups: treatment with VaxSyn, AZT and VaxSyn, and AZT. Our data show no significant modifications in the levels of apoptosis observed in the three groups over the long-term follow-up (up to 720 days). This was not associated with any significant modifications in other clinical or immunological features. However, analysis of apoptosis performed shortly after the first immunization (at days 3 and 7) showed a significant reduction in the rate of apoptosis in patients receiving AZT or AZT and VaxSyn, as compared with patients receiving VaxSyn alone (30.42 +/- 2.52 SE at day 0 and 23.74 +/- 1.84 at day 3; p = 0.039). Our data also indicate that addition of IL-2 in vitro had a significant inhibitory effect on mortality in all the randomization groups, especially in those receiving AZT (alone or in combination with VaxSyn). (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码:715 / 721
页数:7
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