Applications of breath gas analysis in medicine

被引：166
作者：
Amann, A
Poupart, G
Telser, S
Ledochowski, M
Schmid, A
Mechtcheriakov, S
机构：
[1] Univ Innsbruck, Dept Anesthesiol & Crit Care Med, A-6020 Innsbruck, Austria
[2] Leopold Franzens Univ, Dept Phys Chem, Innsbruck, Austria
[3] Swiss Fed Inst Technol, CH-8093 Zurich, Switzerland
[4] Leopold Franzens Univ, Dept Psychiat, Sleep Lab, Innsbruck, Austria
[5] Inst Clin Nutr, Innsbruck, Austria
[6] Leopold Franzens Univ, Dept Psychiat, Innsbruck, Austria
来源：
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2004年 / 239卷 / 2-3期
关键词：
breath test; proton-transfer-reaction mass spectrometry (PTR-MS); volatile organic compound (VOC) sleep;
D O I：
10.1016/j.ijms.2004.08.010
中图分类号：
O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号：
070203 ; 070304 ; 081704 ; 1406 ;
摘要：
Volatile organic compounds (VOCs) in exhaled breath gas provide valuable information about the subjects' physiological and pathophysiological condition. Proton-transfer-reaction mass spectrometry (PTR-MS) allows rapid and online measurements of these substances. We present results of three studies illustrating the potential of breath gas analysis by PTR-MS in various contexts: long-time online monitoring of VOCs in sleeping subjects suggests that VOC profiles are related to sleep stages. Analysis of VOC concentrations in the breath of carbohydrate malabsorbers emphasizes the role played by bacteria in the gut. Finally, we demonstrate the large intra- and intersubject concentration variability of VOCs by considering one particular mass. (C) 2004 Elsevier B.V. All rights reserved.
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收藏
页码：227 / 233
页数：7
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