Palladium-catalysed Grignard cross-coupling using highly concentrated Grignards in methyl-tetrahydrofuran

被引：27
作者：
Milton, Edward J. [1 ]
Clarke, Matthew L. [1 ]
机构：
[1] Univ St Andrews, Sch Chem, EaStCHEM, St Andrews, Fife, Scotland
来源：
GREEN CHEMISTRY | 2010年 / 12卷 / 03期
基金：
英国工程与自然科学研究理事会;
关键词：
ARYL CHLORIDES; ALKYL-HALIDES; REAGENTS; COMPLEXES; ETHERS;
D O I：
10.1039/b921026a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The cross-coupling of Grignard reagents at 5 molar concentration in methyl-tetrahydrofuran with no added reaction solvents can be achieved with the appropriate matching of catalyst to substrate, significantly reducing solvent use when compared to a typical protocol in tetrahydrofuran. Me-THF was also used in an improved microwave accelerated synthesis of the [Pd(L)Cl-2] pre-catalysts from sodium tetrachloropalladate in very high yield.
引用
收藏
页码：381 / 383
页数：3
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