Enantioselective addition of diethylzinc to aryl aldehydes catalyzed by 1,2,3,4-tetrahydroisoquinoline β-amino alcohol

被引：4

作者：

Xu, Geng

Liu, Zhan Zhu ^{[1
]}

机构：

[1] Peking Union Med Coll, Inst Mat Med, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100050, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 03期

关键词：

beta-Amino alcohol; Tetrahydroisoquinoline; Diethylzinc; Asymmetric addition; LIGAND;

D O I：

10.1016/j.cclet.2009.11.046

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly effective, new chiral 1,2,3,4-tetrahydroisoquinoline catalyst 1 for the diethylzinc addition to aryl aldehydes has been investigated. Using 10 mol% of this chiral catalyst, secondary alcohols can be obtained in up to 87% yield and 99.5% ee under mild conditions. (C) 2009 Zhan Zhu Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：309 / 311

页数：3

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