The Poisoned Well: Enhancing the Predictive Value of Antimicrobial Susceptibility Testing in the Era of Multidrug Resistance

被引：25

作者：

Brennan-Krohn, Thea ^{[1
,2
]}

Smith, Kenneth P. ^{[1
]}

Kirby, James E. ^{[1
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Pathol, 330 Brookline Ave, Boston, MA 02215 USA

[2] Boston Childrens Hosp, Div Infect Dis, Boston, MA USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2017年 / 55卷 / 08期

基金：

美国国家卫生研究院;

关键词：

antimicrobial activity; minimal inhibitory concentration; precision; susceptibility testing; ANTIBIOTIC-SENSITIVITY; SYSTEM; ENTEROBACTERIACEAE; METHODOLOGY; PERFORMANCE; PENICILLIN; ACCURACY; INOCULUM; AGENTS;

D O I：

10.1128/JCM.00511-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antimicrobial susceptibility testing (AST) is a fundamental mission of the clinical microbiology laboratory. Reference AST methods are based on bacterial growth in antibiotic doubling dilution series, which means that any error in the reference method inherently represents at least a 2-fold difference. We describe the origins of current AST reference methodology, highlight the sources of AST variability, and propose ideas for improving AST predictive power.

引用

页码：2304 / 2308

页数：5

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