Biodegradable polymers for electrospinning: Towards biomedical applications

被引：289
作者：
Kai, Dan [1 ]
Liow, Sing Shy [1 ]
Loh, Xian Jun [1 ,2 ,3 ]
机构：
[1] ASTAR, IMRE, Singapore 117602, Singapore
[2] Natl Univ Singapore, Dept Mat Sci & Engn, Singapore 117576, Singapore
[3] Singapore Eye Res Inst, Singapore 168751, Singapore
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2014年 / 45卷
关键词：
Electrospun nanofibers; Biodegradable polyesters; Tissue engineering; Drug delivery; Biosensors; STEM-CELL DIFFERENTIATION; IN-VITRO DEGRADATION; NANOFIBROUS SCAFFOLDS; COMPOSITE NANOFIBERS; ELECTRICAL-STIMULATION; DRUG-RELEASE; OSTEOGENIC DIFFERENTIATION; SILVER NANOPARTICLES; SUSTAINED DELIVERY; ACID) SCAFFOLDS;
D O I：
10.1016/j.msec.2014.04.051
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Electrospinning has received much attention recently due to the growing interest in nano-technologies and the unique material properties. This review focuses on recent progress in applying electrospinning technique in production of biodegradable nanofibers to the emerging field of biomedical. It first introduces the basic theory and parameters of nanofibers fabrication, with focus on factors affecting the morphology and fiber diameter of biodegradable nanofibers. Next, commonly electrospun biodegradable nanofibers are discussed, and the comparison of the degradation rate of nanoscale materials with macroscale materials are highlighted. The article also assesses the recent advancement of biodegradable nanofibers in different biomedical applications, including tissue engineering, drug delivery, biosensor and immunoassay. Future perspectives of biodegradable nanofibers are discussed in the last section, which emphasizes on the innovation and development in electrospinning of hydrogels nanofibers, pore size control and scale-up productions. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：659 / 670
页数：12
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