Mapping of the α-tectorin gene (TECTA) to mouse chromosome 9 and human chromosome 11:: A candidate for human autosomal dominant nonsyndromic deafness

alpha-Tectorin is one of the major major noncollagenous components of the mammalian tectorial membrane in the inner ear. We have mapped thc gene encoding alpha-tectorin to mouse chromosome 9 and human chromosome 11 in a known region of conserved synteny. Human YAC clones containing alpha-tectorin have bees identified, demonstrating physical linkage to the anonymous marker D11S925. This places alpha-tectorin within the genetic interval that contains both the human nonsyndromic autosomal dominant deafness DFNA12 and the proximal limit of a subset of deletions within Jacobsen syndrome, Thus both DFNA12 and the hearing loss in some cases of Jacobsen syndrome may be due to haploinsufficiency for TECTA. (C) 1998 Academic Press.