The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation

被引：306

作者：

Beavon, IRG ^{[1
]}

机构：

[1] S African Inst Med Res, Sch Pathol, Dept Anat Pathol, Johannesburg, South Africa

[2] Univ Witwatersrand, Johannesburg, South Africa

来源：

EUROPEAN JOURNAL OF CANCER | 2000年 / 36卷 / 13期

关键词：

E-cadherin; catenins; cell adhesion; cell signalling; regulation; tumour metastasis; hypoxia; growth factors; epidermal growth factor receptor;

D O I：

10.1016/S0959-8049(00)00158-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

E-cadherin and the associated catenin complex have been recognised as performing a key role in cell adhesion. Loss of cell adhesion is seen as a key step in the cascade leading to tumour metastasis. The ability of both extra- and intracellular factors to regulate E-cadherin-mediated cell adhesion in physiological processes has provided insight into both the interactions of the E-cadherin-catenin complex, and possible mechanisms utilised by tumours in the process of metastasis. The interaction of thr E-cadherin-catenin complex with various regulating factors, their effect on cell signalling pathways, and the relationship with the metastatic potential of tumours are reviewed. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1607 / 1620

页数：14

共 213 条

[1] beta-catenin is a target for the ubiquitin-proteasome pathway [J].

Aberle, H ;

Bauer, A ;

Stappert, J ;

Kispert, A ;

Kemler, R .

EMBO JOURNAL, 1997, 16 (13) :3797-3804

[2] THE HUMAN PLAKOGLOBIN GENE LOCALIZES ON CHROMOSOME 17Q21 AND IS SUBJECTED TO LOSS OF HETEROZYGOSITY IN BREAST AND OVARIAN CANCERS [J].

ABERLE, H ;

BIERKAMP, C ;

TORCHARD, D ;

SEROVA, O ;

WAGNER, T ;

NATT, E ;

WIRSCHING, J ;

HEIDKAMPER, C ;

MONTAGNA, M ;

LYNCH, HT ;

LENOIR, GM ;

SCHERER, G ;

FEUNTEUN, J ;

KEMLER, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (14) :6384-6388

[3]

ABERLE H, 1994, J CELL SCI, V107, P3655

[4] Cytomechanics of cadherin-mediated cell-cell adhesion [J].

Adams, CL ;

Nelson, WJ .

CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (05) :572-577

[5] Quantitative analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion [J].

Adams, CL ;

Nelson, WJ ;

Smith, SJ .

JOURNAL OF CELL BIOLOGY, 1996, 135 (06) :1899-1911

[6]

Almadori G, 1999, INT J CANCER, V84, P188

[7] Expression of the E-cadherin-catenin cell adhesion complex in primary squamous cell carcinomas of the head and neck and their nodal metastases [J].

Andrews, NA ;

Jones, AS ;

Helliwell, TR ;

Kinsella, AR .

BRITISH JOURNAL OF CANCER, 1997, 75 (10) :1474-1480

[8] Mechanism for transition from initial to stable cell-cell adhesion: Kinetic analysis of E-cadherin-mediated adhesion using a quantitative adhesion assay [J].

Angres, B ;

Barth, A ;

Nelson, WJ .

JOURNAL OF CELL BIOLOGY, 1996, 134 (02) :549-557

[9] p120ctn acts as an inhibitory regulator of cadherin function in colon carcinoma cells [J].

Aono, S ;

Nakagawa, S ;

Reynolds, AB ;

Takeichi, M .

JOURNAL OF CELL BIOLOGY, 1999, 145 (03) :551-562

[10] SOLUBLE FORMS OF THE ADHESION MOLECULE E-CADHERIN IN URINE [J].

BANKS, RE ;

PORTER, WH ;

WHELAN, P ;

SMITH, PH ;

SELBY, PJ .

JOURNAL OF CLINICAL PATHOLOGY, 1995, 48 (02) :179-180

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