Cellular damage in bacterial meningitis: An interplay of bacterial and host driven toxicity

被引:46
作者
Weber, Joerg R.
Tuomanen, Elaine I.
机构
[1] Univ Med Berlin, Dept Cell Biol & Neurobiol, Charite, D-10117 Berlin, Germany
[2] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA
关键词
meningitis; innate immunity; neuronal damage; cell death; microglia;
D O I
10.1016/j.jneuroim.2006.11.016
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Bacterial meningitis is still an important infectious disease causing death and disability. Invasive bacterial infections of the CNS generate some of the most powerful inflammatory responses known in medicine. Although the components of bacterial cell surfaces are now chemically defined in exquisite detail and the interaction with several receptor pathways has been discovered, it is only very recently that studies combining these advanced biochemical and cell biological tools have been done. Additional to the immunological response direct bacterial toxicity has been identified as an important contributor to neuronal damage. A detailed understanding of the complex interaction of bacterial toxicity and host response may generate opportunities for innovative and specific neuroprotective therapies. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:45 / 52
页数:8
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