An Effective Method for Allylic Oxidation of Δ5-Steroids Using tert-Butyl Hydroperoxide

被引：21

作者：

Li, Yuancheng ^{[1
]}

Wu, Xianhong ^{[1
]}

Lee, Tae Bum ^{[1
]}

Isbell, Eleanor K. ^{[1
]}

Parish, Edward J. ^{[1
]}

Gorden, Anne E. V. ^{[1
]}

机构：

[1] Auburn Univ, Dept Chem & Biochem, Coll Sci & Math, Auburn, AL 36849 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 05期

关键词：

DIRHODIUM CAPROLACTAMATE; OXYSTEROLS; 7-KETOCHOLESTEROL; LOCALIZATION; ALKENES; REAGENT;

D O I：

10.1021/jo902637k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An allylic oxidation method for Delta(5)-steroids using TBHP as oxidant with a 2-quinoxalinol salen Cu(II) complex as catalyst is reported. A variety of Delta(5)-steroidal substrates are selectively oxidized to the corresponding enones. Excellent yields are achieved (up to 99% under optimized conditions) while significantly reducing reaction times required as compared to other current methods.

引用

页码：1807 / 1810

页数：4

共 33 条

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