99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: Triggering of autoimmune diseases by infections

被引：39

作者：

Getts, M. T. ^{[1
]}

Miller, S. D. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Microbiol Immunol, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2010年 / 160卷 / 01期

关键词：

autoimmune disease; epitope spreading; infection; molecular mimicry; DEPENDENT DIABETES-MELLITUS; INDUCED MOLECULAR MIMICRY; CENTRAL-NERVOUS-SYSTEM; MYELIN BASIC-PROTEIN; B-CELL TOLERANCE; MULTIPLE-SCLEROSIS; VIRUS-INFECTION; T-CELLS; ENDOGENOUS PRESENTATION; DEMYELINATING DISEASE;

D O I：

10.1111/j.1365-2249.2010.04132.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

P>Human autoimmune diseases, such as multiple sclerosis, type 1 diabetes, rheumatoid arthritis and systemic lupus erythematosus (SLE), are linked genetically to distinct major histocompatibility complex (MHC) class II molecules and other immune modulators. However, genetic predisposition is only one risk factor for the development of these diseases, and low concordance rates in monozygotic twins as well as geographical distribution of disease risk suggest a critical role for environmental factors in the triggering of these autoimmune diseases. Among potential environmental factors, infections have been implicated in the onset and/or promotion of autoimmunity. This review will discuss human autoimmune diseases with a potential viral cause, and outline potential mechanisms by which pathogens can trigger autoimmune disease as discerned from various animal models of infection-induced autoimmune disease.

引用

页码：15 / 21

页数：7

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