Role of the JAK/STAT signal transduction pathway in the regulation of gene expression in CNS

被引：31
|
作者：
Dell'Albani, P
Santangelo, R
Torrisi, L
Nicoletti, VG
Stella, AMG
机构：
[1] CNR, Inst Neurol Sci, I-95123 Catania, Italy
[2] Univ Catania, Dept Chem Sci, Biochem & Mol Biol Sect, I-95125 Catania, Italy
来源：
NEUROCHEMICAL RESEARCH | 2003年 / 28卷 / 01期
关键词：
JAKs; STATs; signal transduction; CNS; gene expression;
D O I：
10.1023/A:1021644027850
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Over the last 20 years the JAK/STAT signal transduction pathway has been extensively studied. An enormous amount of data on different cell signal transduction pathways is now available. The JAK/STAT signal transduction pathway is one of the intracellular signaling pathways activated by cytokines and growth factors that was first studied in the hematopoietic system, but recent data demonstrate that this signal transduction is also greatly utilized by other systems. The JAK/STAT pathway is a signaling cascade that links the activation of specific cell membrane receptors to nuclear gene expression. This review is focused on the role of JAK/STAT signal transduction pathway activation in the central nervous system (CNS).
引用
收藏
页码：53 / 64
页数：12
相关论文
共 50 条
  • [11] Intact JAK-STAT signaling pathway is a prerequisite for STAT1 to reinforce the expression of RIG-G gene
    Lou, Ye-Jiang
    Zhang, Zhang-Lin
    Pan, Xiao-Rong
    Xu, Gui-Ping
    Jia, Pei-Min
    Li, Dong
    Tong, Jian-Hua
    EXPERIMENTAL CELL RESEARCH, 2011, 317 (04) : 513 - 520
  • [12] Regulation of signal transduction pathways and gene expression by mood stabilizers and antidepressants
    Chen, G
    Hasanat, KA
    Bebchuk, JM
    Moore, GJ
    Glitz, D
    Manji, HK
    PSYCHOSOMATIC MEDICINE, 1999, 61 (05): : 599 - 617
  • [13] Signal transduction and regulation of gene expression by prostaglandin nuclear receptor system
    Chen, Y
    Luan, LM
    Yang, ZM
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2004, 31 (03) : 209 - 212
  • [14] Role of the JAK-STAT Pathway in Bovine Mastitis and Milk Production
    Khan, Muhammad Zahoor
    Khan, Adnan
    Xiao, Jianxin
    Ma, Yulin
    Ma, Jiaying
    Gao, Jian
    Cao, Zhijun
    ANIMALS, 2020, 10 (11): : 1 - 16
  • [15] Impact of diabetes on CNS: Role of signal transduction cascade
    Bhardwaj, SK
    Sandhu, SK
    Sharma, P
    Kaur, G
    BRAIN RESEARCH BULLETIN, 1999, 49 (03) : 155 - 162
  • [16] Neurohormone signal transduction for dual regulation of metabolism and gene expression in insects: Hypertrehalosemic hormone as a model
    Keeley, LL
    Park, JH
    Lu, KH
    Bradfield, JY
    ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY, 1996, 33 (3-4) : 283 - 301
  • [17] The neurobiology of bipolar disorder: Focus on signal transduction pathways and the regulation of gene expression
    Bezchlibnyk, Y
    Young, LT
    CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2002, 47 (02): : 135 - 148
  • [18] Unique signal transduction of Eyk: Constitutive stimulation of the JAK-STAT pathway by an oncogenic receptor-type tyrosine kinase
    Zong, C
    Yan, RQ
    August, A
    Darnell, JE
    Hanafusa, H
    EMBO JOURNAL, 1996, 15 (17) : 4515 - 4525
  • [19] JAK/STAT Signal Transduction: Promising Attractive Targets for Immune, Inflammatory and Hematopoietic Diseases
    Gao, Qianwen
    Liang, Xuewu
    Shaikh, Abdul Sami
    Zang, Jie
    Xu, Wenfang
    Zhang, Yingjie
    CURRENT DRUG TARGETS, 2018, 19 (05) : 487 - 500
  • [20] Cytokine receptor signal transduction through Jak tyrosine kinases and Stat transcription factors
    Silvennoinen, O
    Saharinen, P
    Paukku, K
    Takaluoma, K
    Kovanen, P
    APMIS, 1997, 105 (07) : 497 - 509
12345