Role of the JAK/STAT signal transduction pathway in the regulation of gene expression in CNS

被引：31
|
作者：
Dell'Albani, P
Santangelo, R
Torrisi, L
Nicoletti, VG
Stella, AMG
机构：
[1] CNR, Inst Neurol Sci, I-95123 Catania, Italy
[2] Univ Catania, Dept Chem Sci, Biochem & Mol Biol Sect, I-95125 Catania, Italy
来源：
NEUROCHEMICAL RESEARCH | 2003年 / 28卷 / 01期
关键词：
JAKs; STATs; signal transduction; CNS; gene expression;
D O I：
10.1023/A:1021644027850
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Over the last 20 years the JAK/STAT signal transduction pathway has been extensively studied. An enormous amount of data on different cell signal transduction pathways is now available. The JAK/STAT signal transduction pathway is one of the intracellular signaling pathways activated by cytokines and growth factors that was first studied in the hematopoietic system, but recent data demonstrate that this signal transduction is also greatly utilized by other systems. The JAK/STAT pathway is a signaling cascade that links the activation of specific cell membrane receptors to nuclear gene expression. This review is focused on the role of JAK/STAT signal transduction pathway activation in the central nervous system (CNS).
引用
收藏
页码：53 / 64
页数：12
相关论文
共 50 条
  • [1] Role of the JAK/STAT Signal Transduction Pathway in the Regulation of Gene Expression in CNS
    P. Dell'Albani
    R. Santangelo
    L. Torrisi
    V. G. Nicoletti
    A. M. Giuffrida Stella
    Neurochemical Research, 2003, 28 : 53 - 64
  • [2] A MAJOR ROLE FOR THE PROTEIN-TYROSINE KINASE JAK1 IN THE JAK/STAT SIGNAL-TRANSDUCTION PATHWAY IN RESPONSE TO INTERLEUKIN-6
    GUSCHIN, D
    ROGERS, N
    BRISCOE, J
    WITTHUHN, B
    WATLING, D
    HORN, F
    PELLEGRINI, S
    YASUKAWA, K
    HEINRICH, P
    STARK, GR
    IHLE, JN
    KERR, IM
    EMBO JOURNAL, 1995, 14 (07) : 1421 - 1429
  • [3] Stem cell factor, the JAK-STAT pathway and signal transduction
    Linnekin, D
    Mou, S
    Deberry, CS
    Weiler, SR
    Keller, JR
    Ruscetti, FW
    Longo, DL
    LEUKEMIA & LYMPHOMA, 1997, 27 (5-6) : 439 - 444
  • [4] The role of the JAK/STAT signal pathway in rheumatoid arthritis
    Malemud, Charles J.
    THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE, 2018, 10 (5-6) : 117 - 127
  • [5] The Jak-STAT pathway: Specific signal transduction from the cell membrane to the nucleus
    Heim, MH
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1996, 26 (01) : 1 - 12
  • [6] Urokinase activates the Jak/Stat signal transduction pathway in human vascular endothelial cells
    Dumler, I
    Kopmann, A
    Weis, A
    Mayboroda, OA
    Wagner, K
    Gulba, DC
    Haller, H
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (02) : 290 - 297
  • [7] Targeting JAK-STAT signal transduction in IBD
    Soendergaard, Christoffer
    Bergenheim, Fredrik Holmberg
    Bjerrum, Jakob Tveiten
    Nielsen, Ole Haagen
    PHARMACOLOGY & THERAPEUTICS, 2018, 192 : 100 - 111
  • [8] Prostanoid signal transduction and gene expression in the endothelium:: Role in cardiovascular diseases
    Alfranca, Arantzazu
    Iniguez, Miguel A.
    Fresno, Manuel
    Redondo, Juan Miguel
    CARDIOVASCULAR RESEARCH, 2006, 70 (03) : 446 - 456
  • [9] Gene Expression Regulation and the Signal Transduction of Programmed Cell Death
    Deng, Yuxin
    Li, Kexin
    Yan, Wenxin
    Li, Ke
    Wang, Changshan
    CURRENT ISSUES IN MOLECULAR BIOLOGY, 2024, 46 (09) : 10264 - 10298
  • [10] INTERFERON INDUCTION OF GENE-EXPRESSION THROUGH THE JAK-STAT PATHWAY
    LEVY, DE
    SEMINARS IN VIROLOGY, 1995, 6 (03): : 181 - 189
12345