Maternal iron deficiency anemia (IDA) is associated with risk of adverse perinatal outcomes. Oral iron is recommended to reverse anemia, but has gastrointestinal toxicity and frequent non-adherence. Intravenous (IV) iron is reserved for intolerance of, or unresponsiveness to, oral therapy, malabsorption, and severe anemia (1% with hemoglobin [Hgb] levels <7 g/dL). With rare (<100 per one million) adverse events (AEs) ability to infuse a sufficient dose of low molecular weight iron dextran (LMWID) over 60 min, LMWID is an attractive option. This study demonstrated safety and efficacy of rapid IV infusion of 1,000 mg LMWID to gravidas with moderate to severe IDA. An observational treatment study of 1,000 mg LMWID administered over 1 hr for IDA in 189 consecutive, unselected second and third trimester gravidas after oral iron failure was conducted. All received a test dose of 25 mg LMWID and were monitored for AEs during the 60-min infusion. No premedication was administered unless more than one drug allergy or asthma was present in which case IV methylprednisolone was administered. All were followed through pregnancy and delivery. Monitored parameters included Hgb, mean corpuscular volume, serum ferritin, and percent transferrin saturation. About 189 subjects received 1,000 mg LMWID. No serious AEs occurred. About 2% experienced transient infusion reactions. Hgb improved by 1-1.9 g/dL in 82% and >= 2 g/dL in 24%. Second trimester treatment was not associated with greater Hgb improvement than third trimester treatment. Anemia resolved in 95%. Administration of a single large dose of IV LMWID was effective, safe, and convenient. (C) 2016 Wiley Periodicals, Inc.
机构:
Univ Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, France
Hop Henri Mondor, Etab Franc Sang Ile France, INSERM, U955, Paris, FranceUniv Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, France
Mahevas, Matthieu
Ebbo, Mikael
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AP HP, Hop Concept, Dept Internal Med, Marseille, FranceUniv Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, France
Ebbo, Mikael
Audia, Sylvain
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Hop Univ Dijon, Dept Internal Med, Dijon, FranceUniv Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, France
Audia, Sylvain
Bonnotte, Bernard
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Hop Univ Dijon, Dept Internal Med, Dijon, FranceUniv Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, France
Bonnotte, Bernard
Schleinitz, Nicolas
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AP HP, Hop Concept, Dept Internal Med, Marseille, FranceUniv Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, France
Schleinitz, Nicolas
Durand, Jean-Marc
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AP HP, Hop Concept, Dept Internal Med, Marseille, FranceUniv Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, France
Durand, Jean-Marc
Chiche, Laurent
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AP HP, Hop Concept, Dept Internal Med, Marseille, FranceUniv Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, France
Chiche, Laurent
Khellaf, Medhi
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Univ Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, FranceUniv Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, France
Khellaf, Medhi
Bierling, Philippe
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Univ Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, France
Hop Henri Mondor, Etab Franc Sang Ile France, INSERM, U955, Paris, FranceUniv Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, France
Bierling, Philippe
Roudot-Thoraval, Francoise
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Univ Paris Est Creteil, Dept Publ Hlth, Creteil, FranceUniv Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, France
Roudot-Thoraval, Francoise
Godeau, Bertrand
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Univ Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, FranceUniv Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, France
Godeau, Bertrand
Michel, Marc
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Univ Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, FranceUniv Paris Est Creteil, AP HP, Hop Henri Mondor,Dept Internal Med, Ctr Reference Cytopenies Autoimmunes Adulte, Creteil, France
机构:
Launceston Gen Hosp, Haematol, Launceston, Tas, Australia
Univ Tasmania, Sch Human Life Sci, Launceston, Tas, AustraliaLaunceston Gen Hosp, Haematol, Launceston, Tas, Australia
Khalafallah, A.
Dennis, A.
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Launceston Gen Hosp, Obstetr & Gynaecol, Launceston, Tas, AustraliaLaunceston Gen Hosp, Haematol, Launceston, Tas, Australia
机构:
Gen Hosp Ciudad Victoria Dr Norberto Trevino Zapa, Dept Gynecol & Obstet, Ciudad Victoria, Tamaulipas, MexicoGen Hosp Ciudad Victoria Dr Norberto Trevino Zapa, Dept Gynecol & Obstet, Ciudad Victoria, Tamaulipas, Mexico
Rodrigo Sanchez-Gonzalez, Luis
Enrique Castro-Melendez, Simon
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Gen Hosp Ciudad Victoria Dr Norberto Trevino Zapa, Dept Gynecol & Obstet, Ciudad Victoria, Tamaulipas, MexicoGen Hosp Ciudad Victoria Dr Norberto Trevino Zapa, Dept Gynecol & Obstet, Ciudad Victoria, Tamaulipas, Mexico
Enrique Castro-Melendez, Simon
Cristina Angeles-Torres, Alejandra
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Gen Hosp Ciudad Victoria Dr Norberto Trevino Zapa, Dept Gynecol & Obstet, Ciudad Victoria, Tamaulipas, MexicoGen Hosp Ciudad Victoria Dr Norberto Trevino Zapa, Dept Gynecol & Obstet, Ciudad Victoria, Tamaulipas, Mexico
Cristina Angeles-Torres, Alejandra
Castro-Cortina, Nohemi
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机构:
Gen Hosp Ciudad Victoria Dr Norberto Trevino Zapa, Dept Anesthesiol, Ciudad Victoria, Tamaulipas, MexicoGen Hosp Ciudad Victoria Dr Norberto Trevino Zapa, Dept Gynecol & Obstet, Ciudad Victoria, Tamaulipas, Mexico
Castro-Cortina, Nohemi
Escobar-Valenci, Alfredo
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Gen Hosp Ciudad Victoria Dr Norberto Trevino Zapa, Dept Gynecol & Obstet, Ciudad Victoria, Tamaulipas, MexicoGen Hosp Ciudad Victoria Dr Norberto Trevino Zapa, Dept Gynecol & Obstet, Ciudad Victoria, Tamaulipas, Mexico
Escobar-Valenci, Alfredo
Quiroga-Garza, Alejandro
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Univ Autonoma Nuevo Leon, Fac Med, Nuevo Leon, MexicoGen Hosp Ciudad Victoria Dr Norberto Trevino Zapa, Dept Gynecol & Obstet, Ciudad Victoria, Tamaulipas, Mexico