The Anti-Inflammatory Compound Curcumin Enhances Locomotor and Sensory Recovery after Spinal Cord Injury in Rats by Immunomodulation

被引：46

作者：

Urdzikova, Lucia Machova ^{[1
]}

Karova, Kristyna ^{[1
,2
]}

Ruzicka, Jiri ^{[1
,2
]}

Kloudova, Anna ^{[1
]}

Shannon, Craig ^{[3
]}

Dubisova, Jana ^{[1
,2
]}

Murali, Raj ^{[3
]}

Kubinova, Sarka ^{[1
]}

Sykova, Eva ^{[1
,2
]}

Jhanwar-Uniyal, Meena ^{[3
]}

Jendelova, Pavla ^{[1
,2
]}

机构：

[1] Acad Sci Czech Republ, Inst Expt Med, Videnska 1083, Prague 14220, Czech Republic

[2] Charles Univ Prague, Dept Neurosci, Fac Med 2, Prague 14220, Czech Republic

[3] New York Med Coll, New York, NY 10595 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 01期

关键词：

spinal cord injury; curcumin; inflammation; cytokines; secondary processes; NF-kappa B; NF-KAPPA-B; STEM-CELLS; PROMOTES; INHIBITION; EXPRESSION; PATHWAY; CANCER; MMP-9;

D O I：

10.3390/ijms17010049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Well known for its anti-oxidative and anti-inflammation properties, curcumin is a polyphenol found in the rhizome of Curcuma longa. In this study, we evaluated the effects of curcumin on behavioral recovery, glial scar formation, tissue preservation, axonal sprouting, and inflammation after spinal cord injury (SCI) in male Wistar rats. The rats were randomized into two groups following a balloon compression injury at the level of T9-T10 of the spinal cord, namely vehicle-or curcumin-treated. Curcumin was applied locally on the surface of the injured spinal cord immediately following injury and then given intraperitoneally daily; the control rats were treated with vehicle in the same manner. Curcumin treatment improved behavioral recovery within the first week following SCI as evidenced by improved Basso, Beattie, and Bresnahan (BBB) test and plantar scores, representing locomotor and sensory performance, respectively. Furthermore, curcumin treatment decreased glial scar formation by decreasing the levels of MIP1 alpha, IL-2, and RANTES production and by decreasing NF-kappa B activity. These results, therefore, demonstrate that curcumin has a profound anti-inflammatory therapeutic potential in the treatment of spinal cord injury, especially when given immediately after the injury.

引用

页数：15

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