Microprocessor of microRNAs: regulation and potential for therapeutic intervention

被引：71
作者：
Beezhold, Kevin J. [1 ,2 ]
Castranova, Vince [1 ]
Chen, Fei [1 ,2 ]
机构：
[1] NIOSH, Lab Canc Signaling & Epigenet, Hlth Effects Lab Div, Pathol & Physiol Res Branch, Morgantown, WV 26505 USA
[2] W Virginia Univ, Canc Cell Biol Program, Morgantown, WV 26506 USA
来源：
MOLECULAR CANCER | 2010年 / 9卷
关键词：
RNA-INTERFERENCE; NUCLEAR EXPORT; PROSTATE-CANCER; BINDING-PROTEIN; OVARIAN-CANCER; MESSENGER-RNA; CELL-GROWTH; COMPLEX; RECOGNITION; MIR-34A;
D O I：
10.1186/1476-4598-9-134
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MicroRNAs (miRNAs) are a class of small, noncoding RNAs critically involved in a wide spectrum of normal and pathological processes of cells or tissues by fine-tuning the signals important for stem cell development, cell differentiation, cell cycle regulation, apoptosis, and transformation. Considerable progress has been made in the past few years in understanding the transcription, biogenesis and functional regulation of miRNAs. Numerous studies have implicated altered expression of miRNAs in human cancers, suggesting that aberrant expression of miRNAs is one of the hallmarks for carcinogenesis. In this review, we briefly discuss most recent discoveries on the regulation of miRNAs at the level of microprocessor-mediated biogenesis of miRNAs.
引用
收藏
页数：9
相关论文
共 72 条
[1]  
[Anonymous], 2007, SCI SINGAL, DOI DOI 10.1126/STKE.3672007RE1
[2]   MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].
Asangani, I. A. ;
Rasheed, S. A. K. ;
Nikolova, D. A. ;
Leupold, J. H. ;
Colburn, N. H. ;
Post, S. ;
Allgayer, H. .
ONCOGENE, 2008, 27 (15) :2128-2136
[3]   The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor [J].
Bates, GJ ;
Nicol, SM ;
Wilson, BJ ;
Jacobs, AMF ;
Bourdon, JC ;
Wardrop, J ;
Gregory, DJ ;
Lane, DP ;
Perkins, ND ;
Fuller-Pace, FV .
EMBO JOURNAL, 2005, 24 (03) :543-553
[4]   Role for a bidentate ribonuclease in the initiation step of RNA interference [J].
Bernstein, E ;
Caudy, AA ;
Hammond, SM ;
Hannon, GJ .
NATURE, 2001, 409 (6818) :363-366
[5]   Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs [J].
Bohnsack, MT ;
Czaplinski, K ;
Görlich, D .
RNA, 2004, 10 (02) :185-191
[6]   The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities [J].
Bonci, Desiree ;
Coppola, Valeria ;
Musumeci, Maria ;
Addario, Antonio ;
Giuffrida, Raffaella ;
Memeo, Lorenzo ;
D'Urso, Leonardo ;
Pagliuca, Alfredo ;
Biffoni, Mauro ;
Labbaye, Catherine ;
Bartucci, Monica ;
Muto, Giovanni ;
Peschle, Cesare ;
De Maria, Ruggero .
NATURE MEDICINE, 2008, 14 (11) :1271-1277
[7]   How do microRNAs regulate gene expression? [J].
Cannell, Ian G. ;
Kong, Yi Wen ;
Bushell, Martin .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2008, 36 :1224-1231
[8]   MicroRNAs modulate hematopoietic lineage differentiation [J].
Chen, CZ ;
Li, L ;
Lodish, HF ;
Bartel, DP .
SCIENCE, 2004, 303 (5654) :83-86
[9]   Regulation of IKKβ by miR-199a affects NF-κB activity in ovarian cancer cells [J].
Chen, R. ;
Alvero, A. B. ;
Silasi, D. A. ;
Kelly, M. G. ;
Fest, S. ;
Visintin, I. ;
Leiser, A. ;
Schwartz, P. E. ;
Rutherford, T. ;
Mor, G. .
ONCOGENE, 2008, 27 (34) :4712-4723
[10]   Role of miR-143 targeting KRAS in colorectal tumorigenesis [J].
Chen, X. ;
Guo, X. ;
Zhang, H. ;
Xiang, Y. ;
Chen, J. ;
Yin, Y. ;
Cai, X. ;
Wang, K. ;
Wang, G. ;
Ba, Y. ;
Zhu, L. ;
Wang, J. ;
Yang, R. ;
Zhang, Y. ;
Ren, Z. ;
Zen, K. ;
Zhang, J. ;
Zhang, C-Y .
ONCOGENE, 2009, 28 (10) :1385-1392
12345678