An All-in-One Organic Semiconductor for Targeted Photoxidation Catalysis in Hypoxic Tumor

被引:48
作者
Chen, Weihua [1 ]
Sun, Zhen [1 ]
Jiang, Chunhuan [1 ]
Sun, Wenbo [2 ]
Yu, Bin [1 ]
Wang, Wei [1 ]
Lu, Lehui [1 ]
机构
[1] Univ Sci & Technol China, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Peoples R China
[2] Qingdao Univ, Shandong Sino Japanese Ctr Collaborat Res Carbon, Coll Mat Sci & Engn, Coll Chem & Chem Engn,Instrumental Anal Ctr, Qingdao 266071, Peoples R China
基金
中国国家自然科学基金;
关键词
cancer therapy; organic semiconductors; photoxidation; EFFICIENT PHOTODYNAMIC THERAPY; ANTIBACTERIAL PROPERTIES; HYPERBARIC-OXYGEN; NANOPARTICLES; MECHANISM; CANCER;
D O I
10.1002/anie.202105206
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Tumor hypoxia severely limits the therapeutic effects of photodynamic therapy (PDT). Although many methods for oxygen generation exist, substantial safety concerns, spatiotenporal uncontrollability, limited efficacy, and complicated procedures have compromised their practical application. Here, we demonstrate a biocompatiable all-in-one organic semiconductor to provide a photoxidation catalysis mechanism of action. A facile method is developed to produce gram-level C5N2 nanoparticles (NPs)-based organic semiconductor. Under 650 nm laser irradiation, the semiconductor split water to generate O-2 and simultaneously produce singlet oxygen (O-1(2)), showing that the photocatalyst for O-2 evolution and the photosensitizer (PS) for O-1(2) generation could be synchronously achieved in one organic semiconductor. The inherent nucleus targeting capacity endows it with direct and efficient DNA photocleavage. These findings pave the way for developing organic semiconductor-based cancer therapeutic agents.
引用
收藏
页码:16641 / 16648
页数:8
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