Vascular endothelium - Gatekeeper of vessel health

被引：365
作者：
Cahill, Paul A. [1 ]
Redmond, Eileen M. [2 ]
机构：
[1] Dublin City Univ, Vasc Biol & Therapeut Lab, Dublin 9, Ireland
[2] Univ Rochester, Med Ctr, Dept Surg, Box SURG,601 Elmwood Ave, Rochester, NY 14642 USA
来源：
ATHEROSCLEROSIS | 2016年 / 248卷
关键词：
Endothelium; Endothelial dysfunction; Atherosclerosis; Cardiovascular disease; Vessel remodeling; Clinical therapies; Review; FLUID SHEAR-STRESS; LOW-DENSITY-LIPOPROTEIN; NITRIC-OXIDE SYNTHASE; PROTEIN-KINASE-C; PLASMINOGEN-ACTIVATOR INHIBITOR-1; TO-MESENCHYMAL TRANSITION; REGULAR PHYSICAL-EXERCISE; CORONARY-ARTERY-DISEASE; FACTOR-B CHAIN; SMOOTH-MUSCLE;
D O I：
10.1016/j.atherosclerosis.2016.03.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The vascular endothelium is an interface between the blood stream and the vessel wall. Changes in this single cell layer of the artery wall are believed of primary importance in the pathogenesis of vascular disease/atherosclerosis. The endothelium responds to humoral, neural and especially hemodynamic stimuli and regulates platelet function, inflammatory responses, vascular smooth muscle cell growth and migration, in addition to modulating vascular tone by synthesizing and releasing vasoactive substances. Compromised endothelial function contributes to the pathogenesis of cardiovascular disease; endothelial 'dysfunction' is associated with risk factors, correlates with disease progression, and predicts cardiovascular events. Therapies for atherosclerosis have been developed, therefore, that are directed towards improving endothelial function. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：97 / 109
页数：13
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