Antidermatophyte activity of syzygium aromaticum, petroselinum crispum, and tetrapleura tetraptera

Introduction: The increasing incidence of dermatophytoses in the world and the side effects of the drugs used encouraged the search of alternative drugs. Hence, the objective of this work was to determine antidermatophyte activity of Syzygium aromaticum seed, Petroselinum crispum leaves, and Tetrapleura tetraptera fruits. Methods: The extracts were prepared by maceration of plant materials into 70% ethanol and methanol. The phytochemical screening was carried out on the extracts. The antidermatophyte assay was performed by the agar dilution method. Results: The results showed that the extraction yields ranged from 9.83% to 32.96%. The phytochemical screening revealed the presence of phenol, glucosides, anthraquinones, and tannins in all extracts. The 70% ethanolic and methanolic extracts of S. aromaticum showed significant inhibition following the preliminary screening. The methanolic extract of S. aromaticum portrayed the best activity with MIC ranging from 0.3125 to 0.625 mg/ml. Conclusions: These results show that the methanolic extract of S. aromaticum seed is promising in the treatment of dermatophytosis, as an alternative in the development of a new therapy.