Ruthenium-Catalyzed Tandem-Isomerization/Asymmetric Transfer Hydrogenation of Allylic Alcohols

被引：37

作者：

Slagbrand, Tove ^{[1
]}

Lundberg, Helena ^{[1
]}

Adolfsson, Hans ^{[1
]}

机构：

[1] Univ Stockholm, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 49期

基金：

瑞典研究理事会;

关键词：

allylic alcohols; asymmetric catalysis; isomerization; reduction; ruthenium; ASYMMETRIC TRANSFER HYDROGENATION; HIGHLY EFFICIENT CATALYSTS; ARYL ALKYL KETONES; REDOX ISOMERIZATION; CARBONYL-COMPOUNDS; SATURATED KETONES; AQUEOUS-MEDIA; COMPLEXES; REDUCTION; LIGANDS;

D O I：

10.1002/chem.201405207

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-pot procedure for the direct conversion of racemic allylic alcohols to enantiomerically enriched saturated alcohols is presented. The tandem-isomerization/asymmetric transfer hydrogenation process is efficiently catalyzed by [{Ru(p-cymene)Cl-2}(2)] in combination with the -amino acid hydroxyamide ligand 1, and performed under mild conditions in a mixture of ethanol and THF. The saturated alcohol products are isolated in good to excellent chemical yields and in enantiomeric excess up to 93%.

引用

页码：16102 / 16106

页数：5

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