Multi-omics approaches to disease

被引：1494

作者：

Hasin, Yehudit ^{[1
,3
]}

Seldin, Marcus ^{[1
]}

Lusis, Aldons ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, Dept Med, 10833 Le Conte Ave,A2-237 CHS, Los Angeles, CA 90095 USA

[2] Immunol & Mol Genet, Dept Microbiol, 10833 Le Conte Ave,A2-237 CHS, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Human Genet, 10833 Le Conte Ave,A2-237 CHS, Los Angeles, CA 90095 USA

来源：

GENOME BIOLOGY | 2017年 / 18卷

关键词：

GENOME-WIDE ASSOCIATION; LONG NONCODING RNA; ENU MOUSE MUTAGENESIS; GENE-EXPRESSION; PROTEOMIC ANALYSIS; MASS-SPECTROMETRY; CIRCULAR RNAS; DIFFERENTIAL EXPRESSION; MICROBIOTA COMPOSITION; TRANSCRIPTOME ANALYSIS;

D O I：

10.1186/s13059-017-1215-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

High-throughput technologies have revolutionized medical research. The advent of genotyping arrays enabled large-scale genome-wide association studies and methods for examining global transcript levels, which gave rise to the field of "integrative genetics". Other omics technologies, such as proteomics and metabolomics, are now often incorporated into the everyday methodology of biological researchers. In this review, we provide an overview of such omics technologies and focus on methods for their integration across multiple omics layers. As compared to studies of a single omics type, multi-omics offers the opportunity to understand the flow of information that underlies disease.

引用

页数：15

共 179 条

[81] DNA Methylation as a Biomarker for Cardiovascular Disease Risk [J].

Kim, Myungjin ;

Long, Tiffany I. ;

Arakawa, Kazuko ;

Wang, Renwei ;

Yu, Mimi C. ;

Laird, Peter W. .

PLOS ONE, 2010, 5 (03)

[82] Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies [J].

Klindworth, Anna ;

Pruesse, Elmar ;

Schweer, Timmy ;

Peplies, Joerg ;

Quast, Christian ;

Horn, Matthias ;

Gloeckner, Frank Oliver .

NUCLEIC ACIDS RESEARCH, 2013, 41 (01)

[83] Long non-coding RNAs as regulators of the endocrine system [J].

Knoll, Marko ;

Lodish, Harvey F. ;

Sun, Lei .

NATURE REVIEWS ENDOCRINOLOGY, 2015, 11 (03) :151-160

[84] Single cell sequencing reveals low levels of aneuploidy across mammalian tissues [J].

Knouse, Kristin A. ;

Wu, Jie ;

Whittaker, Charles A. ;

Amon, Angelika .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (37) :13409-13414

[85] The Next-Generation Sequencing Revolution and Its Impact on Genomics [J].

Koboldt, Daniel C. ;

Steinberg, Karyn Meltz ;

Larson, David E. ;

Wilson, Richard K. ;

Mardis, Elaine R. .

CELL, 2013, 155 (01) :27-38

[86] Integrative analysis of 111 reference human epigenomes [J].

Kundaje, Anshul ;

Meuleman, Wouter ;

Ernst, Jason ;

Bilenky, Misha ;

Yen, Angela ;

Heravi-Moussavi, Alireza ;

Kheradpour, Pouya ;

Zhang, Zhizhuo ;

Wang, Jianrong ;

Ziller, Michael J. ;

Amin, Viren ;

Whitaker, John W. ;

Schultz, Matthew D. ;

Ward, Lucas D. ;

Sarkar, Abhishek ;

Quon, Gerald ;

Sandstrom, Richard S. ;

Eaton, Matthew L. ;

Wu, Yi-Chieh ;

Pfenning, Andreas R. ;

Wang, Xinchen ;

Claussnitzer, Melina ;

Liu, Yaping ;

Coarfa, Cristian ;

Harris, R. Alan ;

Shoresh, Noam ;

Epstein, Charles B. ;

Gjoneska, Elizabeta ;

Leung, Danny ;

Xie, Wei ;

Hawkins, R. David ;

Lister, Ryan ;

Hong, Chibo ;

Gascard, Philippe ;

Mungall, Andrew J. ;

Moore, Richard ;

Chuah, Eric ;

Tam, Angela ;

Canfield, Theresa K. ;

Hansen, R. Scott ;

Kaul, Rajinder ;

Sabo, Peter J. ;

Bansal, Mukul S. ;

Carles, Annaick ;

Dixon, Jesse R. ;

Farh, Kai-How ;

Feizi, Soheil ;

Karlic, Rosa ;

Kim, Ah-Ram ;

Kulkarni, Ashwinikumar .

NATURE, 2015, 518 (7539) :317-330

[87] The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases [J].

Laakso, Markku ;

Kuusisto, Johanna ;

Stancakova, Alena ;

Kuulasmaa, Teemu ;

Pajukanta, Paivi ;

Lusis, Aldons J. ;

Collins, Francis S. ;

Mohlke, Karen L. ;

Boehnke, Michael .

JOURNAL OF LIPID RESEARCH, 2017, 58 (03) :481-493

[88] Single nucleotide polymorphism arrays: a decade of biological, computational and technological advances [J].

LaFramboise, Thomas .

NUCLEIC ACIDS RESEARCH, 2009, 37 (13) :4181-4193

[89] Eigengene networks for studying the relationships between co-expression modules [J].

Langfelder, Peter ;

Horvath, Steve .

BMC SYSTEMS BIOLOGY, 2007, 1 :54

[90] Microbial ecology - Human gut microbes associated with obesity [J].

Ley, Ruth E. ;

Turnbaugh, Peter J. ;

Klein, Samuel ;

Gordon, Jeffrey I. .

NATURE, 2006, 444 (7122) :1022-1023

← 4 5 6 7 8 9 10 11 12 13 →