AKT and its related molecular feature in aged mice skin

被引：24

作者：

Chen, Haiyan ^{[1
,2
,3
]}

Wang, Xusheng ^{[2
]}

Han, Jimin ^{[2
,4
]}

Fan, Zhimeng ^{[2
,4
]}

Sadia, Sobia ^{[2
]}

Zhang, Rongrong ^{[5
]}

Guo, Yingsheng ^{[6
]}

Jiang, Yuyang ^{[3
]}

Wu, Yaojiong ^{[1
,2
]}

机构：

[1] Tsinghua Univ, Tsinghua Berkeley Shenzhen Inst, Shenzhen, Peoples R China

[2] Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Hlth Sci & Technol, Shenzhen, Peoples R China

[3] Shenzhen Ctr Dis Control & Prevent, Med Key Lab Hlth Toxicol Shenzhen, Shenzhen, Peoples R China

[4] Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China

[5] Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Nephrol, Shenzhen, Peoples R China

[6] Second Peoples Hosp Futian Dist, Shenzhen, Peoples R China

来源：

PLOS ONE | 2017年 / 12卷 / 06期

关键词：

FACTOR-KAPPA-B; CELL-PROLIFERATION; PTEN; INFLAMMATION; ACTIVATION; EXPRESSION; PATHWAY; CANCER; REDUCTION;

D O I：

10.1371/journal.pone.0178969

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Previous studies suggest that Akt signaling promotes tissue regeneration and decreased Akt activities are found in aged tissues. However, this study finds that the expression and activation levels of Akt in the mice skin increased with age. Additionally, the expression levels of Pten, p16, p21 and p53 also elevated with increased age. Immuno-fluorescence analysis showed that Akt phosphorylation found in the epidermal cells (with increased levels of NF-kappa B activation) were also found. In vivo inhibition of AKT activity result in reduced NF-kappa B activation. Our results suggest that increasing Akt/NF-kappa B is a crucial mediator of skin aging, which can increase the susceptibility of cell transformation.

引用

页数：12

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