Radiochemical separation of no-carrier-added 177Lu as produced via the 176Yb(n,γ)177Yb→177Lu process

被引：77
作者：
Lebedev, NA
Novgorodov, AF
Misiak, R
Brockmann, J
Rösch, F
机构：
[1] Univ Mainz, Inst Kernchem, D-55128 Mainz, Germany
[2] Joint Inst Nucl Res Dubna, Lab Nucl Problems, Dubna, Russia
[3] H Niewodniczanski Inst Nucl Phys, PL-31342 Krakow, Poland
来源：
APPLIED RADIATION AND ISOTOPES | 2000年 / 53卷 / 03期
关键词：
Lu-177; endoradiotherapy; specific activity; cementation;
D O I：
10.1016/S0969-8043(99)00284-5
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The Yb-176(n,y)Yb-177-beta(-)-->Lu-177 process was investigated to provide no-carrier-added (nca) Lu-177. Th, radiochemical separation of the Lu-177 From the macro-amounts of the ytterbium target based on the cementation process, i.e, the selective extraction of Yb by Na(Hg) amalgam from Cl-/CH3COO- electrolytes, followed by a final cation exchange purification. The cementation separation process provides a decontamination factor of Yb(III) of 10(4), the cation exchange purification adding a decontamination factor of >10(2). The nea Lu-177 is available in radiochemically pure form despite the chemical similarity of the lanthanides with 75 +/- 5% overall separation yield within 4-5 h. It can be used to synthesise nea Lu-177 labelled radiotherapeuticals. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：421 / 425
页数：5
相关论文
共 13 条
  • [1] BUGAJ JE, 1999, J NUCL MED, V40
  • [2] Production and radiochemical separation of Gd-147
    Denzler, FO
    Lebedev, NA
    Novgorodov, AF
    Rosch, F
    Qaim, SM
    [J]. APPLIED RADIATION AND ISOTOPES, 1997, 48 (03) : 319 - 326
  • [3] ERION JL, 1999, J MED MED, V40
  • [4] Separation of carrier free lutetium produced in proton activated ytterbium with HDEHP
    Lahiri, S
    Nayak, D
    Nandy, M
    Das, NR
    [J]. APPLIED RADIATION AND ISOTOPES, 1998, 49 (08) : 911 - 913
  • [5] MARSH JK, 1943, J CHEM SOC, V2, P531
  • [6] MARSH JK, 1943, J CHEM SOC, V2, P8
  • [7] MARSH JK, 1942, J CHEM SOC, V1, P523
  • [8] MARSH JK, 1942, J CHEM SOC, V1, P398
  • [9] Mulligan T, 1995, CLIN CANCER RES, V1, P1447
  • [10] NGUEN KT, 1985, P685253 JINR
12